环孢素A增强链脲佐菌素诱导的CD-1小鼠糖尿病。
Cyclosporin A enhances streptozocin-induced diabetes in CD-1 mice.
作者信息
Iwakiri R, Nagafuchi S, Kounoue E, Nakano S, Koga T, Nakayama M, Nakamura M, Niho Y
出版信息
Experientia. 1987 Mar 15;43(3):324-7. doi: 10.1007/BF01945570.
PMID:2951271
Abstract
Cyclosporin A (CYA), when administered to CD-1 mice treated with a subdiabetogenic dose of Streptozocin (STZ), exacerbated the STZ-induced insulitis and elevated the plasma glucose levels, parallel to a reduction of the insulin content of the pancreas. The possible mechanisms of CYA-mediated aggravation of STZ-induced diabetes are discussed.
摘要
将环孢菌素A（CYA）给予用亚糖尿病剂量链脲佐菌素（STZ）处理的CD-1小鼠时，会加剧STZ诱导的胰岛炎并升高血糖水平，同时胰腺胰岛素含量降低。本文讨论了CYA介导的STZ诱导糖尿病加重的可能机制。
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