Velázquez-Dohorn Magali Evangelina, López-Durand Carlos Fernando, Gamboa-Domínguez Armando
Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Rev Invest Clin. 2018;70(1):40-45. doi: 10.24875/RIC.17002430.
The prevalence of gastric polyps varies around the world reflecting regional associations. We describe demographic features of patients with gastric polyp diagnosis treated between 1980 and 2016 at a referral center in Mexico City and analyzed trends of polyp subtype.
We conducted a blind review of archival slides of gastric biopsies with polyp diagnosis from the years 1980, 1990, 2000, 2010, and 2016. Initial diagnosis; patient's gender, age and symptoms; and number and location of lesions were recorded. Blind slide review and trend analysis were performed.
In 3887 gastric biopsies, 192 patients (4.93%) with epithelial polyps were identified. The median age of patients was 58 years; 73% were female. Polyps were single in 143/192 cases (74.4%), almost 67% in the oxyntic mucosa, and 85% were associated with dyspepsia. The prevalence was 0.5%, 1.6%, 1.9%, 4.6%, and 9.6% for the years 1980, 1990, 2000, 2010, and 2016, respectively, resulting in a rising trend in the prevalence of epithelial polyps of 380% in 46 years. Fundic gland polyps (FGPs) had a global frequency of 66.6% (128/192). They were identified for the first time in the third period of the study, with a frequency of 28.6% (6/21), 66.6% (35/53), and 78.3% (87/111) for the years 2000, 2010, and 2016, respectively. Contrary, hyperplastic polyps (HPs) decreased 20%. A relative prevalence of 3.29%, 0.97%, and 0.15% was observed for FGP, HP, and gastric adenoma, respectively.
The 1400% change of FGP explains the increased prevalence of gastric polyps. Chronic treatment with proton pump inhibitors and Helicobacter pylori eradication are possible explanations.
胃息肉的患病率在世界各地有所不同，反映出地区差异。我们描述了1980年至2016年在墨西哥城一家转诊中心接受治疗的胃息肉诊断患者的人口统计学特征，并分析了息肉亚型的趋势。
我们对1980年、1990年、2000年、2010年和2016年诊断为胃息肉的胃活检存档玻片进行了盲法审查。记录初始诊断、患者的性别、年龄和症状以及病变的数量和位置。进行了盲法玻片审查和趋势分析。
在3887例胃活检中，鉴定出192例（4.93%）上皮性息肉患者。患者的中位年龄为58岁；73%为女性。192例中有143例（74.4%）息肉为单发，近67%位于胃底黏膜，85%与消化不良相关。1980年、1990年、2000年、2010年和2016年的患病率分别为(0.5%)、(1.6%)、(1.9%)、(4.6%)和(9.6%)，导致上皮性息肉患病率在46年中上升了380%。胃底腺息肉（FGP）的总体发生率为66.6%（128/192）。它们在研究的第三个时期首次被发现，2000年、2010年和2016年的发生率分别为28.6%（6/21）、66.6%（35/53）和78.3%（87/111）。相反，增生性息肉（HP）减少了20%。FGP、HP和胃腺瘤的相对患病率分别为3.29%、0.97%和0.15%。
FGP的1400%变化解释了胃息肉患病率的增加。质子泵抑制剂的长期治疗和幽门螺杆菌的根除可能是原因。
