a Department of Ophthalmology , School of Medicine, Pusan National University , Busan , South Korea.
c Biomedical Research Institute , School of Medicine, Pusan National University Hospital , Busan , South Korea.
Ocul Immunol Inflamm. 2019;27(4):583-590. doi: 10.1080/09273948.2018.1433303. Epub 2018 Mar 7.
: To assess the value of positive immunoglobulin (Ig) M serum antibody (Ab) findings in uveitis patients. : We reviewed medical records of patients who had a positive serological test for gondii-specific IgM Ab. Their clinical data, including history, demographic characteristics, laboratory findings, clinical findings, treatment outcomes, and recurrences, were reviewed retrospectively. : Of 2919 uveitis patients who underwent a serological test for suspected ocular toxoplasmosis (OT), 18 presented with positive Ig M results. All 18 patients (100.0% specificity) were clinically diagnosed with OT. None had any retinochoroidal scar at the initial visit, indicating the OT was a recent and primary infection. However, 15 patients (83.3%) had no history suspected to account for the transmission. : The IgM serum Ab is a specific biomarker for diagnosis of primary OT. Epidemiological studies are warranted to investigate the non-classic transmission routes of in OT.
评估葡萄膜炎患者血清免疫球蛋白 M（IgM）抗体阳性结果的价值。
我们回顾了血清弓形虫特异性 IgM 抗体阳性患者的病历。回顾性分析了他们的临床资料，包括病史、人口统计学特征、实验室检查结果、临床检查结果、治疗效果和复发情况。
在 2919 例疑似眼弓形体病（OT）患者中进行了血清学检查，18 例患者 IgM 结果阳性。所有 18 例患者（特异性 100.0%）均临床诊断为 OT。初次就诊时，所有患者均无视网膜脉络膜瘢痕，提示 OT 为近期原发性感染。然而，15 例患者（83.3%）无已知的传播途径。
IgM 血清 Ab 是诊断原发性 OT 的特异性生物标志物。有必要进行流行病学研究以探讨 OT 中弓形虫的非经典传播途径。
