一种B细胞特异性分化抗原CD23是淋巴细胞上IgE（FcεR）的受体。
A B cell-specific differentiation antigen, CD23, is a receptor for IgE (Fc epsilon R) on lymphocytes.
作者信息
Yukawa K, Kikutani H, Owaki H, Yamasaki K, Yokota A, Nakamura H, Barsumian E L, Hardy R R, Suemura M, Kishimoto T
出版信息
J Immunol. 1987 Apr 15;138(8):2576-80.
Two independent L cell transformants expressing human lymphocyte Fc epsilon R were established by using cellular DNA from RPMI 8866 cells. The surface expression of the receptor was confirmed on the basis of the binding of a panel of anti-Fc epsilon R antibodies and its ability to bind IgE. Anti-CD23 antibodies strongly stained the transformants, indicating possible identity or antigenic relationship between Fc epsilon R and CD23. This interesting observation warrants additional clarification as to the role of CD23 and Fc epsilon R in B cell differentiation.
利用RPMI 8866细胞的细胞DNA建立了两个表达人淋巴细胞FcεR的独立L细胞转化体。根据一组抗FcεR抗体的结合及其结合IgE的能力，证实了受体的表面表达。抗CD23抗体强烈染色转化体，表明FcεR与CD23之间可能存在同一性或抗原关系。这一有趣的观察结果有待进一步阐明CD23和FcεR在B细胞分化中的作用。
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