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Update on the Management of Rosacea from the American Acne & Rosacea Society (AARS).美国痤疮与酒渣鼻协会（AARS）发布的酒渣鼻管理最新情况。
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本文引用的文献

1
Dual anti-inflammatory and anti-parasitic action of topical ivermectin 1% in papulopustular rosacea.局部用伊维菌素 1%具有双重抗炎和抗寄生虫作用。在脓疱性酒渣鼻中的应用。
J Eur Acad Dermatol Venereol. 2017 Nov;31(11):1907-1911. doi: 10.1111/jdv.14437. Epub 2017 Aug 29.
2
Topical Treatment of Rosacea with Ivermectin Inhibits Gene Expression of Cathelicidin Innate Immune Mediators, LL-37 and KLK5, in Reconstructed and Ex Vivo Skin Models.伊维菌素局部治疗酒渣鼻可抑制重组皮肤模型和体外皮肤模型中抗菌肽天然免疫介质LL-37和激肽释放酶5（KLK5）的基因表达。
Dermatol Ther (Heidelb). 2017 Jun;7(2):213-225. doi: 10.1007/s13555-017-0176-3. Epub 2017 Feb 27.
3
Ivermectin therapy for papulopustular rosacea and periorificial dermatitis in children: A series of 15 cases.伊维菌素治疗儿童丘疹脓疱型酒渣鼻和口周皮炎：15例系列病例
J Am Acad Dermatol. 2017 Mar;76(3):567-570. doi: 10.1016/j.jaad.2016.10.034.
4
Treatment of rosacea with topical ivermectin cream: a series of 34 cases.外用伊维菌素乳膏治疗酒渣鼻：34例病例系列
Dermatol Online J. 2016 Aug 15;22(8):13030/qt9ks1c48n.
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Two Consecutive Standardized Skin Surface Biopsies: An Improved Sampling Method to Evaluate Demodex Density as a Diagnostic Tool for Rosacea and Demodicosis.两次连续标准化皮肤表面活检：一种改进的采样方法，用于评估蠕形螨密度，作为酒渣鼻和蠕形螨病的诊断工具。
Acta Derm Venereol. 2017 Feb 8;97(2):242-248. doi: 10.2340/00015555-2528.
6
The efficacy, safety, and tolerability of ivermectin compared with current topical treatments for the inflammatory lesions of rosacea: a network meta-analysis.与当前治疗酒渣鼻炎性皮损的局部治疗方法相比，伊维菌素的疗效、安全性及耐受性：一项网状Meta分析。
Springerplus. 2016 Jul 22;5(1):1151. doi: 10.1186/s40064-016-2819-8. eCollection 2016.
7
Facial Erythema of Rosacea - Aetiology, Different Pathophysiologies and Treatment Options.玫瑰痤疮的面部红斑——病因、不同病理生理学及治疗选择
Acta Derm Venereol. 2016 Jun 15;96(5):579-86. doi: 10.2340/00015555-2335.
8
Maintenance of remission following successful treatment of papulopustular rosacea with ivermectin 1% cream vs. metronidazole 0.75% cream: 36-week extension of the ATTRACT randomized study.1%伊维菌素乳膏与0.75%甲硝唑乳膏成功治疗丘疹脓疱型玫瑰痤疮后的缓解维持：ATTRACT随机研究的36周延长期
J Eur Acad Dermatol Venereol. 2016 May;30(5):829-36. doi: 10.1111/jdv.13537. Epub 2015 Dec 21.
9
Interventions for Rosacea.酒渣鼻治疗方法。
JAMA. 2015 Dec 8;314(22):2403-4. doi: 10.1001/jama.2015.15287.
10
Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors.酒渣鼻：第一部分。引言、分类、组织病理学、发病机制和危险因素。
J Am Acad Dermatol. 2015 May;72(5):749-58; quiz 759-60. doi: 10.1016/j.jaad.2014.08.028.

外用伊维菌素：支持酒渣鼻双重作用模式的数据。

Topical Ivermectin: Data Supporting Dual Modes of Action in Rosacea.

作者信息

Del Rosso James Q

机构信息

Dr. Del Rosso is Research Director at JDR Dermatology Research in Las Vegas, Nevada; Adjunct Clinical Professor of Dermatology at Touro University Nevada, Las Vegas; and with Dermatology and Cutaneous Surgery at Thomas Dermatology in Las Vegas, Nevada.

出版信息

J Clin Aesthet Dermatol. 2017 Sep;10(9):39-42. Epub 2017 Sep 1.

PMID:29515751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5749619/
Abstract

Until recently, the potential modes of action of topical ivermectin in rosacea have been speculated but not studied. Short-term studies (12 week), long-term studies (up to 52 weeks), and case report series have now been completed, and topical ivermectin (IVM), formulated as a 1% cream that is applied once daily, has been shown to be effective, well-tolerated, and safe for the treatment of rosacea. This article reviews outcomes from studies that support dual modes of action, including both anti-inflammatory and anti-parasitic effects.

摘要

直到最近，外用伊维菌素治疗酒渣鼻的潜在作用方式一直是推测性的，尚未得到研究。目前，短期研究（12周）、长期研究（长达52周）以及病例报告系列均已完成，外用伊维菌素（IVM）制成1%乳膏，每天涂抹一次，已被证明对治疗酒渣鼻有效、耐受性良好且安全。本文综述了支持双重作用方式的研究结果，包括抗炎和抗寄生虫作用。