Deeg K H, Gerstner R, Bundscherer F, Harai G, Singer H, Gutheil H
Monatsschr Kinderheilkd. 1987 Jan;135(1):24-9.
Pulsed doppler recordings were obtained in the truncus coeliacus in 12 premature born infants (gestational age 30.3 +/- 2.5 weeks) with the clinical signs of patent ductus arteriosus Botalli (PDA) and compared to a control group of 24 healthy infants (gestational age 40.5 +/- 5.3 weeks). In all children the maximal systolic velocity, the endsystolic and the enddiastolic velocity and the pulsatility-index were measured. The 24 healthy newborns showed the following velocities: Maximal systolic velocity: 77 +/- 16 cm X s-1; endsystolic velocity: 31 +/- 10 cm X s-1; enddiastolic velocity; 18 +/- 9 cm X s-1. The pulsatility-index was 0.75 +/- 0.11. In children with PDA the maximal systolic velocity was 72 +/- 21 cm X s-1, the endsystolic velocity 15 +/- 14 cm X s-1 and the enddiastolic velocity -5 +/- 8 cm X s-1. The pulsatility-index was 1.08 +/- 0.12. All infants with large PDA showed a significant decrease of the endsystolic velocity and enddiastolic velocity, whereas the pulsatility-index was significantly increased. The decrease of the endsystolic and enddiastolic velocity in infants with large PDA in comparison to the healthy control group may lead to hypoxemic-ischemic lesions of the intestinal organs. The increased incidence of necrotizing enterocolitis in premature infants with large PDA may be the result of hypoperfusion of the small bowel.
对12例有动脉导管未闭（PDA）临床体征的早产婴儿（胎龄30.3±2.5周）进行腹腔干的脉冲多普勒记录，并与24例健康婴儿（胎龄40.5±5.3周）的对照组进行比较。测量了所有儿童的最大收缩期速度、收缩末期和舒张末期速度以及搏动指数。24例健康新生儿的速度如下：最大收缩期速度：77±16cm·s⁻¹；收缩末期速度：31±10cm·s⁻¹；舒张末期速度：18±9cm·s⁻¹。搏动指数为0.75±0.11。患有PDA的儿童最大收缩期速度为72±21cm·s⁻¹，收缩末期速度为15±14cm·s⁻¹，舒张末期速度为-5±8cm·s⁻¹。搏动指数为1.08±0.12。所有患有大型PDA的婴儿收缩末期速度和舒张末期速度均显著降低，而搏动指数显著升高。与健康对照组相比，患有大型PDA的婴儿收缩末期和舒张末期速度降低可能导致肠道器官的低氧缺血性损伤。患有大型PDA的早产婴儿坏死性小肠结肠炎发病率增加可能是小肠灌注不足的结果。
