Oliveira Cristiano Claudino, Paschoalini Rafael Bispo, Domingues Maria Aparecida Custódio
São Paulo State University (UNESP), Botucatu School of Medicine (FMB), Department of Pathology. Botucatu, SP, Brazil.
PhD Pathology Laboratory. São Paulo, SP, Brazil.
Autops Case Rep. 2018 Feb 27;8(1):e2018001. doi: 10.4322/acr.2018.001. eCollection 2018 Jan-Mar.
Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic sarcoma. The markers CD163, CD68, vimentin, lysozyme, and S-100 were positive in all cases. Similarly, the three samples were positive for Fas-ligand and Caspase-3. It is well-known that neoplasms may induce increased levels of Fas-ligand with the blockade of the apoptosis process. In the context of HS, the increased Fas-ligand expression represents a new area for research. Indeed, it is linked to proinflammatory stimulus and, maybe with the association of an infection.
组织细胞肉瘤（HS）是一种罕见的造血系统起源的恶性肿瘤，病因不明。我们研究了3例组织细胞肉瘤患者，回顾其形态学和免疫组化特征。我们特别评估了在这种疾病中细胞凋亡是否可能失衡。所有病例均具有符合组织细胞肉瘤诊断的形态学和免疫组化特征。所有病例中CD163、CD68、波形蛋白、溶菌酶和S-100标记均为阳性。同样，这三个样本Fas配体和半胱天冬酶-3均为阳性。众所周知，肿瘤可能通过阻断凋亡过程诱导Fas配体水平升高。在HS的背景下，Fas配体表达增加是一个新的研究领域。事实上，它与促炎刺激有关，也可能与感染有关。
