Leussink Verena Isabell
Neurologische Klinik, Medizinische Fakultät, Heinrich-Heine-Universität, Moorenstraße 5, 40225, Düsseldorf, Deutschland.
Neurologie in Meerbusch, 40667, Meerbusch, Deutschland.
Nervenarzt. 2019 Aug;90(8):843-857. doi: 10.1007/s00115-019-0756-9.
Chronic neurodegenerative and neuroinflammatory diseases, such as idiopathic Parkinson's syndrome, amyotrophic lateral sclerosis and multiple sclerosis, represent a therapeutic challenge. Their pathophysiology is not well understood and a cure for any of these diseases is not possible. Over the past decades lifestyle and nutritional habits in modern industrial nations have changed and evidence is increasing that the prevalence of chronic diseases as well their clinical presentation are also changing. Epidemiological investigations indicate that nutritional components might have an impact on the pathogenesis of chronic neurological diseases. A profound understanding of these correlations could foster a better prevention as well as treatment of such chronic disabling diseases. This continuing medical education article summarizes the current understanding of selected nutritional components and their effect on the development and clinical course of chronic neurological disorders.
慢性神经退行性疾病和神经炎症性疾病,如特发性帕金森综合征、肌萎缩侧索硬化症和多发性硬化症,是治疗上的一大挑战。其病理生理学尚未完全明确,目前尚无治愈这些疾病的方法。在过去几十年里,现代工业化国家的生活方式和营养习惯发生了变化,越来越多的证据表明,慢性病的患病率及其临床表现也在改变。流行病学调查表明,营养成分可能对慢性神经疾病的发病机制产生影响。深入了解这些关联有助于更好地预防和治疗此类慢性致残性疾病。这篇继续医学教育文章总结了目前对特定营养成分及其对慢性神经疾病发展和临床过程影响的理解。