Panerai A E, Sacerdote P, Brini A, Mantegazza P
Neurosci Lett. 1987 Mar 9;74(3):348-52. doi: 10.1016/0304-3940(87)90322-3.
Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function of beta-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine. All 3 experimental approaches resulted in a decrease of the analgesia induced by morphine, thus suggesting that beta-endorphin is involved in the effect of morphine.
辣椒素是一种神经毒性剂，可导致下丘脑β-内啡肽减少，一种特异性抗血清和人β-内啡肽片段6 - 31（一种肽能β-内啡肽拮抗剂）已被用于试图选择性地影响β-内啡肽能系统的功能，并评估该肽在吗啡镇痛作用中可能的作用。所有这三种实验方法都导致吗啡诱导的镇痛作用减弱，因此表明β-内啡肽参与了吗啡的作用。
