Rubio C A, Llatjós M
Acta Cytol. 1979 Nov-Dec;23(6):504-6.
The rate of cell production in the squamous cervical epithelium, as deduced from the number of arrested mitoses at various time intervals after a single injection of vincristine, was investigated in 83 C57B1 mice. In the basal cell layer several peaks of arrested mitoses were registered: the first major peak was found at 9 hours, the second at 12 hours, the third at 16 hours and the fourth at 20 hours. Distinct peaks of arrested mitosis were also found in the nonbasal (parabasal) cell layers. Each mitotic peak may correspond to a number of cells that had entered the proliferative pool from the "resting" compartment. The stathmokinetic effect of vincristine on the squamous cervical epithelium had ceased after 20 hours.
通过单次注射长春新碱后不同时间间隔处停滞有丝分裂的数量推断，对83只C57B1小鼠的宫颈鳞状上皮细胞产生速率进行了研究。在基底细胞层记录到了几个停滞有丝分裂的峰值：第一个主要峰值出现在9小时，第二个在12小时，第三个在16小时，第四个在20小时。在非基底（副基底）细胞层也发现了明显的停滞有丝分裂峰值。每个有丝分裂峰值可能对应于一定数量从“静止”区室进入增殖池的细胞。长春新碱对宫颈鳞状上皮的有丝分裂抑制作用在20小时后停止。
