Beyer-Boon M E, Rubio C A
Oncology. 1980;37(1):27-9. doi: 10.1159/000225396.
The rate of cell division during a 6-hour period of time was determined in cervices from 31 mice, 16 having normal epithelium, 8 with atypical epithelium and 7 with invasive carcinoma. Cervical atypias and carcinoma were induced by local application of benzo(a)pyrene (BP) and mitosis was arrested with vincrotal number of cells in all layers as well as the proportion of dividing cells in the parabasal layer were significantly greater in atypias and invasin cell production in that layer.
在6小时时间段内，测定了31只小鼠子宫颈的细胞分裂速率，其中16只具有正常上皮组织，8只具有非典型上皮组织，7只患有浸润性癌。通过局部应用苯并(a)芘（BP）诱导子宫颈非典型增生和癌，并用长春花碱阻止有丝分裂。非典型增生和浸润性癌中所有层的细胞总数以及副基底层中分裂细胞的比例均显著更高，该层中的细胞产生情况也是如此。
