• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

PharmGKB summary: clobazam pathway, pharmacokinetics.

作者信息

Huddart Rachel, Leeder J Steven, Altman Russ B, Klein Teri E

机构信息

Departments of Biomedical Data Sciences.

Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, Missouri, USA.

出版信息

Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327.

DOI:10.1097/FPC.0000000000000327
PMID:29517622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5914180/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390b/5914180/1549ae734f6d/nihms959706f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390b/5914180/1549ae734f6d/nihms959706f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390b/5914180/1549ae734f6d/nihms959706f1.jpg

相似文献

1
PharmGKB summary: clobazam pathway, pharmacokinetics.PharmGKB总结：氯巴占途径，药代动力学。
Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327.
2
Clobazam for patients with Lennox-Gastaut syndrome and epilepsy.氯巴占治疗 Lennox-Gastaut 综合征伴癫痫患者。
Expert Rev Neurother. 2012 Apr;12(4):385-93. doi: 10.1586/ern.12.14.
3
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.Dravet 综合征中大麻二酚的随机、剂量范围安全性试验。
Neurology. 2018 Apr 3;90(14):e1204-e1211. doi: 10.1212/WNL.0000000000005254. Epub 2018 Mar 14.
4
A Comprehensive Overview of the Clinical Pharmacokinetics of Clobazam.氯巴占临床药代动力学全面概述。
J Clin Pharmacol. 2019 Jan;59(1):7-19. doi: 10.1002/jcph.1313. Epub 2018 Oct 4.
5
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome.患有德雷维特综合征的患者在长期丙戊酸、氯巴占和左乙拉西坦治疗药物监测期间的药代动力学变异性
Ther Drug Monit. 2020 Oct;42(5):744-753. doi: 10.1097/FTD.0000000000000781.
6
Re: Efficacy of Cannabidiol in Subjects with Refractory Epilepsy Relative to Concomitant Use of Clobazam.回复：相对于联合使用氯巴占，大麻二酚对难治性癫痫患者的疗效。
Epilepsy Res. 2022 Feb;180:106285. doi: 10.1016/j.eplepsyres.2020.106285. Epub 2020 Feb 3.
7
Clobazam : in patients with Lennox-Gastaut syndrome.氯巴占：用于 Lennox-Gastaut 综合征患者。
CNS Drugs. 2012 Nov;26(11):983-91. doi: 10.1007/s40263-012-0007-0.
8
Clobazam for treatment of epilepsy.氯巴占治疗癫痫。
Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13.
9
Interaction between sulthiame and clobazam: sulthiame inhibits the metabolism of clobazam, possibly via an action on CYP2C19.舒噻美与氯巴占之间的相互作用：舒噻美可能通过作用于CYP2C19抑制氯巴占的代谢。
Epilepsy Behav. 2014 May;34:124-6. doi: 10.1016/j.yebeh.2014.03.018. Epub 2014 Apr 17.
10
Pharmacokinetic Drug-Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients.抗癫痫药物（包括 CBD）、治疗 COVID-19 药物和营养素之间的药物代谢动力学药物相互作用。
Int J Mol Sci. 2021 Sep 3;22(17):9582. doi: 10.3390/ijms22179582.

引用本文的文献

1
Universal multilayer network embedding reveals a causal link between GABA neurotransmitter and cancer.通用多层网络嵌入揭示了γ-氨基丁酸（GABA）神经递质与癌症之间的因果关系。
BMC Bioinformatics. 2025 Jun 2;26(1):149. doi: 10.1186/s12859-025-06158-5.
2
ADHD in Adults with Epilepsy: A Guide for Neurologists.成人癫痫患者的注意力缺陷多动障碍：神经科医生指南
Epilepsy Behav Rep. 2024 Dec 28;29:100739. doi: 10.1016/j.ebr.2024.100739. eCollection 2025 Mar.
3
Antiseizure Medications: Advancements, Challenges, and Prospects in Drug Development.

本文引用的文献

1
The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs.抗癫痫药物新使用者发生史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症的风险。
Epilepsia. 2017 Dec;58(12):2178-2185. doi: 10.1111/epi.13925. Epub 2017 Oct 13.
2
Serum protein binding of 25 antiepileptic drugs in a routine clinical setting: A comparison of free non-protein-bound concentrations.常规临床环境下 25 种抗癫痫药物的血清蛋白结合率：游离非蛋白结合浓度的比较。
Epilepsia. 2017 Jul;58(7):1234-1243. doi: 10.1111/epi.13802. Epub 2017 May 24.
3
Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.
抗癫痫药物：药物研发的进展、挑战与前景
Curr Neuropharmacol. 2025;23(8):879-906. doi: 10.2174/011570159X323666241029171256.
4
Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management.超难治性癫痫持续状态：预后及管理的最新进展
Aging Dis. 2021 Jul 1;12(4):1097-1119. doi: 10.14336/AD.2021.0302. eCollection 2021 Jul.
5
Pharmacogenomic Biomarkers and Their Applications in Psychiatry.精神医学中的药物基因组学生物标志物及其应用。
Genes (Basel). 2020 Nov 30;11(12):1445. doi: 10.3390/genes11121445.
6
Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.富含大麻二酚的大麻提取物与甲磺酰甲烷联合给药的安全性和分子毒理学意义。
Int J Mol Sci. 2020 Oct 21;21(20):7808. doi: 10.3390/ijms21207808.
7
The Essential Medicinal Chemistry of Cannabidiol (CBD).大麻二酚（CBD）的基础药物化学
J Med Chem. 2020 Nov 12;63(21):12137-12155. doi: 10.1021/acs.jmedchem.0c00724. Epub 2020 Sep 10.
细胞色素P450等位基因的全球分布：群体规模测序项目的荟萃分析
Clin Pharmacol Ther. 2017 Oct;102(4):688-700. doi: 10.1002/cpt.690. Epub 2017 May 26.
4
Correlating blood and urinary concentrations of clobazam doses in Japanese children and adolescents with intractable epilepsy.日本难治性癫痫儿童和青少年中氯巴占剂量的血液和尿液浓度的相关性研究。
Biomed Chromatogr. 2017 Apr;31(4). doi: 10.1002/bmc.3848. Epub 2016 Oct 3.
5
Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC).临床药物遗传学检测结果术语标准化：来自临床药物遗传学实施联盟（CPIC）的共识术语
Genet Med. 2017 Feb;19(2):215-223. doi: 10.1038/gim.2016.87. Epub 2016 Jul 21.
6
The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.氯巴占代谢物N-去甲基氯巴占是一种优先作用于α2的苯二氮䓬类药物，其抗痛觉过敏的治疗窗有所改善。
Neuropharmacology. 2016 Oct;109:366-375. doi: 10.1016/j.neuropharm.2016.07.004. Epub 2016 Jul 5.
7
Drug-metabolism mechanism: Knowledge-based population pharmacokinetic approach for characterizing clobazam drug-drug interactions.药物代谢机制：基于知识的群体药代动力学方法用于表征氯巴占的药物相互作用。
J Clin Pharmacol. 2016 Mar;56(3):365-74. doi: 10.1002/jcph.603. Epub 2015 Sep 29.
8
Stevens-Johnson Syndrome triggered by a combination of clobazam, lamotrigine and valproic acid in a 7-year-old child.一名7岁儿童因氯巴占、拉莫三嗪和丙戊酸联合使用引发史蒂文斯-约翰逊综合征。
Ann Burns Fire Disasters. 2014 Sep 30;27(3):121-5.
9
An integrative population pharmacokinetics approach to the characterization of the effect of hepatic impairment on clobazam pharmacokinetics.一种综合群体药代动力学方法用于表征肝损伤对氯巴占药代动力学的影响。
J Clin Pharmacol. 2016 Feb;56(2):213-22. doi: 10.1002/jcph.586. Epub 2015 Sep 7.
10
Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.氯巴占与大麻二酚在难治性癫痫儿童中的药物相互作用。
Epilepsia. 2015 Aug;56(8):1246-51. doi: 10.1111/epi.13060. Epub 2015 Jun 26.