Rodriguez-Nicolas Antonio, Martínez-Chamorro Alba, Jiménez Pilar, Matas-Cobos Ana M, Redondo-Cerezo Eduardo, Ruiz-Cabello Francisco
Pancreas. 2018 Apr;47(4):400-405. doi: 10.1097/MPA.0000000000001006.
Acute pancreatitis (AP) is severe in up to 20% of patients, with a high mortality rate. Quantification of serum TH1 and TH2 cytokines may provide objective evidence to assess the severity of AP and predict its course.
One hundred seventeen patients were studied, measuring serum concentrations of interleukin (IL)1β, IL2, IL4, IL5, IL6, IL10, IL12p70, IL13, IL18, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN) γ, and tumor necrosis factor (TNF) α.
Significant differences were found between patients with severe AP and those with mild or moderately severe AP in IFN-γ (P < 0.001), IL6 (P < 0.001), TNF-α (P = 0.002), GM-CSF (P < 0.001), IL4 (P = 0.002), IL1b (P = 0.017), and IL13 (P < 0.001) concentrations. Interferon-γ, IL6, and TNF-α were associated with severe AP, whereas GM-CSF, IL4, IL1b, and IL13 were associated with mild or moderately severe AP. The IL13/IFNγ ratio was significantly higher in patients with mild AP (P = 7.36 × 10).
A TH1 profile was associated with severe AP and a TH2 profile with mild or moderately severe AP. We report an IL13/IFNγ ratio of potential value to predict the prognosis in AP.
高达20%的急性胰腺炎（AP）患者病情严重，死亡率高。血清TH1和TH2细胞因子的定量分析可为评估AP的严重程度及预测其病程提供客观依据。
对117例患者进行研究，检测血清白细胞介素（IL）1β、IL2、IL4、IL5、IL6、IL10、IL12p70、IL13、IL18、粒细胞巨噬细胞集落刺激因子（GM-CSF）、干扰素（IFN）γ和肿瘤坏死因子（TNF）α的浓度。
重度AP患者与轻度或中度重度AP患者在IFN-γ（P<0.001）、IL6（P<0.001）、TNF-α（P = 0.002）、GM-CSF（P<0.001）、IL4（P = 0.002）、IL1b（P = 0.017）和IL13（P<0.001）浓度方面存在显著差异。IFN-γ、IL6和TNF-α与重度AP相关，而GM-CSF、IL4、IL1b和IL13与轻度或中度重度AP相关。轻度AP患者的IL13/IFNγ比值显著更高（P = 7.36×10）。
TH1型与重度AP相关，TH2型与轻度或中度重度AP相关。我们报告了IL13/IFNγ比值在预测AP预后方面具有潜在价值。
