Petraglia A, Scarpitta M, Ansalone D, Calvanese R C, De Cataldis G
Respiration. 1986;50 Suppl 2:177-80. doi: 10.1159/000195122.
Fourteen patients with chronic obstructive lung disease (COLD) were studied. All were in a relatively stable clinico-functional state, and bronchospasm was reversible with fenoterol. The study was carried out over 3 days. Duovent and Carbuterol were given at random on the 1st or 3rd day to each patient; the placebo was always given on the 2nd day. Each drug was administered with 2 puffs of a metered-dose aerosol, corresponding to 200 micrograms fenoterol + 80 micrograms ipratropium bromide for Duovent and 200 micrograms of active substance for Carbuterol. The patients were studied for 7 h after administration of the 3 preparations. Ventilatory and cardiocirculatory parameters as well as local and systemic tolerance of the drugs were evaluated. The data show that Douvent has a more rapid and powerful bronchodilator action compared to Carbuterol. The action of Duovent is more constant and prolonged compared to the other drug and acts on both proximal and distal airways. Local and systemic tolerance is excellent for both drugs studied. In conclusion, Duovent is a rational and effective combination in the treatment of bronchospasm.
对14例慢性阻塞性肺疾病（COLD）患者进行了研究。所有患者均处于相对稳定的临床功能状态，且支气管痉挛可被非诺特罗逆转。研究持续了3天。在第1天或第3天给每位患者随机使用多索茶碱和沙丁胺醇；第2天始终给予安慰剂。每种药物均通过定量气雾剂给予2喷，多索茶碱相当于200微克非诺特罗+80微克异丙托溴铵，沙丁胺醇为200微克活性物质。在给予这3种制剂后对患者进行7小时的研究。评估了通气和心血管循环参数以及药物的局部和全身耐受性。数据表明，与沙丁胺醇相比，多索茶碱具有更快、更强的支气管扩张作用。与另一种药物相比，多索茶碱的作用更持久且持续，对近端和远端气道均有作用。所研究的两种药物的局部和全身耐受性均良好。总之，多索茶碱是治疗支气管痉挛的合理有效组合。
