Macaluso S, Del Torre L
Respiration. 1986;50 Suppl 2:222-5. doi: 10.1159/000195132.
Duovent and salbutamol were compared in 15 patients with stabilized, but partially reversible chronic bronchospasm to verify the persistence of therapeutic effect, bronchodilator efficacy and patient compliance to prolonged treatment with these drugs. Results showed: Clinical efficacy; good protection from bronchospasm. Cough, day-time and nocturnal dyspnoea and the number of additional sprays required were better controlled with Duovent. Activity and bronchodilator efficacy: FVC and even more so FEV1 were sufficiently stable in baseline conditions with negligible variations at the various control times with both drugs, although Duovent was slightly more favourable. Bronchodilator efficacy was maintained more significantly with Duovent compared to salbutamol even after 5 h. Patient compliance: this was better with Duovent, both from the patient's personal opinion and because of the fewer number of daily administrations which the patient received (3 instead of 4).
在15例病情稳定但部分可逆的慢性支气管痉挛患者中对多索茶碱（Duovent）和沙丁胺醇进行了比较，以验证这些药物长期治疗的疗效持续性、支气管扩张功效以及患者依从性。结果显示：临床疗效；对支气管痉挛有良好的预防作用。多索茶碱对咳嗽、日间和夜间呼吸困难以及所需额外喷雾次数的控制更佳。活动能力和支气管扩张功效：用力肺活量（FVC），尤其是第一秒用力呼气容积（FEV1）在基线条件下足够稳定，两种药物在各个对照时间的变化均可忽略不计，尽管多索茶碱略显优势。与沙丁胺醇相比，即使在5小时后，多索茶碱维持支气管扩张功效更为显著。患者依从性：无论是从患者个人观点来看，还是因为患者每日给药次数较少（3次而非4次），多索茶碱的患者依从性更佳。
