Simone P, Robuschi M, Vaghi A, Fasano W, Bianco S
Respiration. 1986;50 Suppl 2:209-11. doi: 10.1159/000195129.
In 12 adult asymptomatic, relatively stable adult asthmatics the protective effect of 3 doses (200, 1,000 and 2,000 micrograms) of ipratropium bromide against bronchospasm induced by an ultrasonic mist of distilled water was functionally (sRaw, FEV1) assessed. Ipratropium bromide and placebo were administered as an inhalation powder via a special inhaler in random order and under double-blind conditions at the same time on 4 usually consecutive days 90 min prior to the challenge. A considerable protective effect (clearly inferior, in any case, to that previously observed by us with fenoterol) was demonstrated (% protection approximately equal to 50) without any striking difference among the 3 doses. Mouth dryness (dose-related) was the sole complaint in some patients.
在12名无症状、病情相对稳定的成年哮喘患者中，对3种剂量（200、1000和2000微克）异丙托溴铵预防蒸馏水超声雾化诱发支气管痉挛的保护作用进行了功能评估（比气道阻力、第一秒用力呼气容积）。异丙托溴铵和安慰剂通过特殊吸入器以吸入粉剂形式给药，在激发试验前90分钟，于4个通常连续的日子里，随机且在双盲条件下同时给药。结果显示出相当大的保护作用（无论如何，明显低于我们之前观察到的非诺特罗的保护作用）（保护率约为50%），3种剂量之间无显著差异。口干（与剂量相关）是部分患者唯一的主诉。
