Fontana G, Mugnai M, Cresci F, Panuccio P
Respiration. 1986;50 Suppl 2:201-5. doi: 10.1159/000195127.
We examined 12 non-smoking patients affected by extrinsic bronchial asthma in steady state. Histamine PD20 FEV1 was assessed 4 h after the administration of salbutamol 200 micrograms, a combination of fenoterol 200 micrograms and ipratropium bromide 80 micrograms, and placebo. Despite the absence of any relevant bronchodilator effect, both salbutamol and the combination fenoterol + ipratropium bromide showed a strong protective effect against the bronchial response to histamine compared to placebo, the combination being more effective than salbutamol (p less than 0.05). Our data suggest that, when bronchial challenges with histamine are performed, airway response may be a consequence of both a direct action of such an agent on H1 receptors and of an associated cholinergic reflex.
我们研究了12名处于稳定期的外源性支气管哮喘非吸烟患者。在给予200微克沙丁胺醇、200微克非诺特罗和80微克异丙托溴铵的组合以及安慰剂4小时后，评估组胺PD20 FEV1。尽管没有任何相关的支气管扩张作用，但与安慰剂相比，沙丁胺醇和非诺特罗+异丙托溴铵组合均对组胺引起的支气管反应显示出强大的保护作用，该组合比沙丁胺醇更有效（p<0.05）。我们的数据表明，当用组胺进行支气管激发试验时，气道反应可能是该药物对H1受体的直接作用以及相关胆碱能反射共同作用的结果。
