[Dynamics of the leading risk factors of ischemic heart disease in a male population over 40-years-old according to the results of a prospective epidemiologic study].

The purpose of the survey was to study the time course of the leading CHD risk factors in an open population of men born in 1916-1935 during a prolonged prospective study and to specify CHD interrelationship with new cases of disease and a course of nonfatal CHD. A population of 5000 males from one of the Leningrad districts was examined with an interval of 7.6 yrs. The first screening included 3907 persons, the repeated screening 2096. In the period of observation the number of persons with the absence of leading risk factors decreased (from 11.5 to 9.6%), the frequency of arterial hypertension (AH) increased (from 32.9 to 42.3%), the proportion of examinees with atherogenic dyslipoproteinemia (DLP) remained the same. By the results of the first screening in 50% of the persons with atherogenic DLP the blood lipid composition in 7.6 yrs returned to normal; AH persisted in 80% of the examinees. The presence of the 3 leading risk factors during the first and second screenings was accompanied by the highest frequency of stable CHD and the highest index of new cases of disease.