Tulassay T, Rascher W, Hajdu J, Lang R E, Tóth M, Seri I
Acta Paediatr Scand. 1987 Jan;76(1):42-6. doi: 10.1111/j.1651-2227.1987.tb10412.x.
The role of dopamine (DA) in the activation and/or release of atrial natriuretic peptide (ANP) was investigated in 11 premature infants during the early postnatal period. Mean plasma concentration of ANP and free DA level before DA infusion was 252.6 +/- 210 fmol/ml, and 0.4 +/- 0.2 ng/ml, respectively. DA infusion in a dose of 2 micrograms/kg/min caused a rise in plasma free DA level to 59.7 +/- 21.5 ng/ml and a significant increase in GFR, diuresis, sodium excretion and fractional sodium excretion. The plasma concentration of ANP, however, remained unchanged (252.6 +/- 210.0 vs. 213 +/- 143.0 fmol/ml). Thus, our data failed to demonstrate a stimulatory effect of DA on ANP release in premature infants. The role of the high plasma concentration of ANP in preterm neonates immediately after birth has to be clarified.
在出生后早期，对11例早产儿研究了多巴胺（DA）在心房利钠肽（ANP）激活和/或释放中的作用。多巴胺输注前，ANP的平均血浆浓度和游离DA水平分别为252.6±210 fmol/ml和0.4±0.2 ng/ml。以2微克/千克/分钟的剂量输注多巴胺，使血浆游离DA水平升至59.7±21.5 ng/ml，并使肾小球滤过率、尿量、钠排泄和钠排泄分数显著增加。然而，ANP的血浆浓度保持不变（252.6±210.0与213±143.0 fmol/ml）。因此，我们的数据未能证明多巴胺对早产儿ANP释放有刺激作用。必须阐明出生后即刻早产儿血浆中高浓度ANP的作用。
