免疫吸附法靶向 IgE 抗体治疗特应性皮炎。
Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis.
机构信息
Department of Dermatology, University of Lübeck, Lübeck, Germany.
Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
出版信息
Front Immunol. 2018 Feb 19;9:254. doi: 10.3389/fimmu.2018.00254. eCollection 2018.
Abstract
One major hallmark of atopic dermatitis (AD) is the elevated level of total serum IgE, which has been reported to be partly of the autoreactive type in a subset of patients. Immunoadsorption (IA) has been successfully applied in various classical autoantibody-mediated diseases such as pemphigus. Recent reports proposed the use of IA also for patients with severe AD and high total serum IgE levels. In this mini-review, we summarize the current knowledge about this novel treatment approach for AD and briefly discuss the so far incompletely known role of autoreactive IgE as potential target of IA therapy in this common inflammatory skin disorder.
摘要
特应性皮炎（AD）的一个主要特征是总血清 IgE 水平升高，据报道，在一部分患者中，部分 IgE 为自身反应性。免疫吸附（IA）已成功应用于各种经典的自身抗体介导的疾病，如天疱疮。最近的报告提出，IA 也可用于治疗总血清 IgE 水平高且病情严重的 AD 患者。在这篇迷你综述中，我们总结了目前关于这种新型 AD 治疗方法的知识，并简要讨论了目前尚不完全清楚的自身反应性 IgE 作为 IA 治疗这种常见炎症性皮肤疾病的潜在靶点的作用。
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