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骨骼肌中的B细胞结构组织可识别皮肌炎的亚型。

Architectural B-cell organization in skeletal muscle identifies subtypes of dermatomyositis.

作者信息

Radke Josefine, Koll Randi, Preuße Corinna, Pehl Debora, Todorova Kremena, Schönemann Constanze, Allenbach Yves, Aronica Eleonora, de Visser Marianne, Heppner Frank L, Weis Joachim, Doostkam Soroush, Maisonobe Thierry, Benveniste Olivier, Goebel Hans-Hilmar, Stenzel Werner

机构信息

Author affiliations are provided at the end of the article.

出版信息

Neurol Neuroimmunol Neuroinflamm. 2018 Mar 6;5(3):e451. doi: 10.1212/NXI.0000000000000451. eCollection 2018 May.

DOI:10.1212/NXI.0000000000000451
PMID:29520367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5840889/
Abstract

OBJECTIVE

To study the B-cell content, organization, and existence of distinct B-cell subpopulations in relation to the expression of type 1 interferon signature related genes in dermatomyositis (DM).

METHODS

Evaluation of skeletal muscle biopsies from patients with adult DM (aDM) and juvenile DM (jDM) by histology, immunohistochemistry, electron microscopy, and quantitative reverse-transcription PCR.

RESULTS

We defined 3 aDM subgroups-classic (containing occasional B cells without clusters), B-cell-rich, and follicle-like aDM-further elucidating IM B-lymphocyte maturation and immunity. The quantity of B cells and formation of ectopic lymphoid structures in a subset of patients with aDM were associated with a specific profile of cytokines and chemokines involved in lymphoid neogenesis. Levels of type 1 interferon signature related gene expression paralleled B-cell content and architectural organization and link B-cell immunity to the interferon type I signature.

CONCLUSION

These data corroborate the important role of B cells in DM, highlighting the direct link between humoral mechanisms as key players in B-cell immunity and the role of type I interferon-related immunity.

摘要

目的

研究皮肌炎（DM）中B细胞含量、组织以及不同B细胞亚群的存在与1型干扰素特征相关基因表达的关系。

方法

通过组织学、免疫组织化学、电子显微镜检查和定量逆转录PCR对成年DM（aDM）和青少年DM（jDM）患者的骨骼肌活检样本进行评估。

结果

我们定义了3个aDM亚组——经典型（含有偶尔无聚集的B细胞）、富含B细胞型和滤泡样aDM，进一步阐明了炎性肌病（IM）中B淋巴细胞的成熟和免疫情况。aDM患者亚组中B细胞的数量和异位淋巴结构的形成与参与淋巴新生的特定细胞因子和趋化因子谱相关。1型干扰素特征相关基因的表达水平与B细胞含量和组织结构平行，并将B细胞免疫与I型干扰素特征联系起来。

结论

这些数据证实了B细胞在DM中的重要作用，突出了体液机制作为B细胞免疫中的关键参与者与I型干扰素相关免疫作用之间的直接联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/0c9ba9a673de/NEURIMMINFL2017015487f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/b3b545ed632a/NEURIMMINFL2017015487f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/d0deb00cb7d8/NEURIMMINFL2017015487f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/6dad49144710/NEURIMMINFL2017015487f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/2bdfd3177b4c/NEURIMMINFL2017015487f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/0c9ba9a673de/NEURIMMINFL2017015487f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/b3b545ed632a/NEURIMMINFL2017015487f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/d0deb00cb7d8/NEURIMMINFL2017015487f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/6dad49144710/NEURIMMINFL2017015487f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/2bdfd3177b4c/NEURIMMINFL2017015487f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e22/5840889/0c9ba9a673de/NEURIMMINFL2017015487f5.jpg

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