Cengiz M I, Bagci H, Cengiz S, Yigit S, Cengiz K
Department of Periodontology, Ondokuz Mayis University, Samsun, Turkey.
J Periodontal Res. 2009 Jun;44(3):354-61. doi: 10.1111/j.1600-0765.2008.01115.x. Epub 2008 Oct 7.
Familial Mediterranean fever stimulates a very intense acute-phase reactants response and if left untreated eventually leads to amyloidosis. The aim of this study was to determine the prevalence of periodontal disease among patients with familial Mediterranean fever in the Black Sea region in Turkey and to evaluate whether periodontitis is related to amyloidosis in patients with familial Mediterranean fever.
One-hundred and thirty three patients with familial Mediterranean fever and 50 healthy subjects were included in this study. Periodontal health and disease were evaluated using the gingival index, papillary bleeding index, plaque index and periodontal disease index. The concentrations of serum acute-phase reactants were measured at baseline and at 4-6 wk after completion of the nonsurgical periodontal therapy. Genetic testing for familial Mediterranean fever was performed using the familial Mediterranean fever StripAssay. Kidney biopsy was carried out on all proteinuric patients.
The prevalence of moderate to severe periodontitis in familial Mediterranean fever patients with amyloidosis (80.6%) was significantly greater (p < 0.01) than in familial Mediterranean fever patients without amyloidosis (38%) and in controls (20%). Serum levels of acute-phase reactants in familial Mediterranean fever patients were reduced significantly following nonsurgical periodontal therapy (p < 0.01).
Periodontal therapy seems to reduce the serum levels of acute-phase reactants in patients with familial Mediterranean fever. Therefore, treating periodontitis might help to alleviate the disease burden in patients with familial Mediterranean fever.
家族性地中海热会引发非常强烈的急性期反应物反应，若不治疗最终会导致淀粉样变性。本研究的目的是确定土耳其黑海地区家族性地中海热患者中牙周病的患病率，并评估牙周炎是否与家族性地中海热患者的淀粉样变性有关。
本研究纳入了133例家族性地中海热患者和50名健康受试者。使用牙龈指数、龈乳头出血指数、菌斑指数和牙周疾病指数评估牙周健康与疾病情况。在基线时以及非手术牙周治疗完成后4至6周测量血清急性期反应物的浓度。使用家族性地中海热试纸检测法进行家族性地中海热的基因检测。对所有蛋白尿患者进行肾活检。
患有淀粉样变性的家族性地中海热患者中，中度至重度牙周炎的患病率（80.6%）显著高于（p < 0.01）无淀粉样变性的家族性地中海热患者（38%）和对照组（20%）。非手术牙周治疗后，家族性地中海热患者的血清急性期反应物水平显著降低（p < 0.01）。
牙周治疗似乎可降低家族性地中海热患者的血清急性期反应物水平。因此，治疗牙周炎可能有助于减轻家族性地中海热患者的疾病负担。
