Nakamura Mitsunobu, Ota Fuyuki, Takada Tadao, Akagi Kazuo, Yamana Kazushige
Department of Applied Chemistry, University of Hyogo, Himeji, Japan.
Department of Polymer Chemistry, Kyoto University, Kyoto, Japan.
Chirality. 2018 May;30(5):602-608. doi: 10.1002/chir.22838. Epub 2018 Mar 9.
In this report, we describe the circularly polarized luminescence (CPL) of the RNA duplexes having one to four 2'-O-pyrene modified uridines (Upy) and the DNA duplexes having two, four, and six pyrene modified non-nucleosidic linkers (Py). Both the pyrene π-stack arrays formed on the RNA and DNA double helical structures exhibited pyrene excimer fluorescence. In the pyrene-modified RNA systems, the RNA duplex having four Upys gives CPL emission with g value of <0.01 at 480 nm. The structure of pyrene stacks on the RNA duplex may be rigidly regulated with increase in the Upy domains, which resulted in the CPL emission. In the DNA systems, the pyrene-modified duplexes containing two and four Pys exhibited CPL emission with g values of <0.001 at 505 nm. The pyrene π-stack arrays presented here show CPL emission. However, the g values are relatively small when compared with our previous system consisting of the pyrene-zipper arrays on RNA.
在本报告中，我们描述了含有一至四个2'-O-芘修饰尿苷（Upy）的RNA双链体以及含有两个、四个和六个芘修饰非核苷连接体（Py）的DNA双链体的圆偏振发光（CPL）。在RNA和DNA双螺旋结构上形成的芘π-堆积阵列均表现出芘激基缔合物荧光。在芘修饰的RNA系统中，含有四个Upy的RNA双链体在480 nm处产生g值<0.01的CPL发射。随着Upy结构域的增加，RNA双链体上芘堆积的结构可能受到严格调控，从而产生CPL发射。在DNA系统中，含有两个和四个Py的芘修饰双链体在505 nm处表现出g值<0.001的CPL发射。此处呈现的芘π-堆积阵列显示出CPL发射。然而，与我们之前由RNA上的芘拉链阵列组成的系统相比，g值相对较小。
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