Ollivier J P, Pocholle J P, Gandjbakhch I, Brion R, Quatre J M, De Bourayne J, Droniou J, Cabrol C
Arch Mal Coeur Vaiss. 1986 Nov;79(12):1720-4.
Research into improving the efficacy of laser in the vaporisation of atheromatous plaques has led to the study of their modes of emission and to attempts at changing the natural absorption properties of the target lesion. This was achieved in vitro by incubation with solutions of derived haematoporphyrin and in vivo by oral administration of therapeutic doses of tetracycline. The selective nature of the coloration produced having been proved, the use of appropriate lasers allowed reduction of 50 to 100 p. 100 of the emitted energy; the exploitation of the fluorescent properties of tetracycline, investigated by laser spectrofluoroscopy in this study, has led to the concept of in situ photodiagnosis of the plaque. These results may open up a new field of research into unknown photobiological characteristics radically different to the thermic energy used at present.
关于提高激光汽化动脉粥样硬化斑块疗效的研究，促使人们对其发射模式进行研究，并尝试改变目标病变的自然吸收特性。这在体外通过与血卟啉衍生物溶液孵育实现，在体内通过口服治疗剂量的四环素实现。在证实了所产生的着色具有选择性之后，使用适当的激光可使发射能量降低50%至100%；本研究通过激光荧光光谱法对四环素荧光特性的研究，引出了斑块原位光诊断的概念。这些结果可能会开辟一个全新的研究领域，研究与目前所使用的热能截然不同的未知光生物学特性。
