Ollivier J P, Pocholle J P, Ricordel I, Droniou J, Gandjbakhch I, Cabrol C
Ann Cardiol Angeiol (Paris). 1986 Feb;35(2):81-5.
The setting up of a reliable method for angioplasty by laser irradiation is based. On the one hand, on the simultaneous control of the observed thermal, mechanical and photochemical effects within the atheromatous material and, on the other, on the demonstration of the absence of effects damaging to the arterial tunica. Theoretical modelling and experimental use have together proved the unique importance of pulsed emission, which strongly reduces thermal diffusion. Labelling of the atheromatous plaque by a hematoporphyrin derivative (HPD), as exemplified in the carcinological process, cancels the superficial reflectivity and strongly reduces the diffusion coefficient in the plaque. It confers on it a spectral absorption characteristic which is the basis of the exact physical coupling between the frequency of the exciting radiation and the absorption which generates vaporization in the pathological material. The preparation of chemically more homogeneous HPD and the spectrometric study of other colouring agents in vivo point to a further development of this technique of angioplasty.
通过激光照射建立可靠的血管成形术方法基于以下两点。一方面，要同时控制动脉粥样硬化物质内观察到的热、机械和光化学效应；另一方面，要证明不存在对动脉壁造成损害的效应。理论建模和实验应用共同证明了脉冲发射的独特重要性，它能大大减少热扩散。如在癌症治疗过程中那样，用血卟啉衍生物（HPD）标记动脉粥样硬化斑块，可消除表面反射率并大大降低斑块中的扩散系数。这赋予其一种光谱吸收特性，这是激发辐射频率与在病变物质中产生汽化的吸收之间精确物理耦合的基础。化学上更均匀的HPD的制备以及体内其他着色剂的光谱研究表明了这种血管成形术技术的进一步发展。
