Pfannenstiel Keith, Hayward Reid
Department of Health, Physical Education, Recreation, Emporia State University, Emporia, KS.
School of Sport and Exercise Science, University of Northern Colorado Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO.
J Cardiovasc Pharmacol. 2018 Jun;71(6):332-339. doi: 10.1097/FJC.0000000000000574.
Although highly effective, doxorubicin (DOX) use is limited by a dose-dependent cardiotoxicity. The purpose of this study was to determine whether resistance training (RT) would protect against DOX-induced cardiac dysfunction and determine whether any observed functional preservation is a result of reduced lipid peroxidation or a preservation of the cardiac myosin heavy chain (MHC) isoform distribution. Rats were resistance-trained or remained sedentary for 12 weeks, then treated with 12.5 mg/kg DOX or 0.9% saline. Five days after DOX exposure, cardiac function, lipid peroxidation, and MHC isoform expression were quantified. RT preserved cardiac function and attenuated the α-to β-MHC shift that occurs with DOX treatment. No significant differences in lipid peroxidation were observed between sedentary and RT animals treated with DOX. These data suggest that resistance-type exercise can provide protection against DOX-induced cardiac dysfunction, which may be a result of a preservation of the cardiac MHC isoform distribution.
尽管阿霉素（DOX）非常有效，但其使用受到剂量依赖性心脏毒性的限制。本研究的目的是确定抗阻训练（RT）是否能预防DOX诱导的心脏功能障碍，并确定观察到的任何功能保留是否是脂质过氧化减少或心肌肌球蛋白重链（MHC）同工型分布保留的结果。大鼠进行12周的抗阻训练或保持久坐不动，然后用12.5mg/kg DOX或0.9%生理盐水治疗。DOX暴露5天后，对心脏功能、脂质过氧化和MHC同工型表达进行定量。抗阻训练保留了心脏功能，并减弱了DOX治疗时发生的α-MHC向β-MHC的转变。在接受DOX治疗的久坐不动和抗阻训练的动物之间，未观察到脂质过氧化有显著差异。这些数据表明，抗阻型运动可以预防DOX诱导的心脏功能障碍，这可能是心脏MHC同工型分布保留的结果。
