Roberts E, Bologa L, Flood J F, Smith G E
Brain Res. 1987 Mar 17;406(1-2):357-62. doi: 10.1016/0006-8993(87)90807-9.
Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amnesia and enhanced long-term memory. By minimizing degenerative changes in injured nerve tissue and facilitating plastic changes, DHEA and DHEAS may be of use in treatment of neurodegenerative and memory disorders in man.
低浓度的脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEAS）可增强14日龄小鼠胚胎脑解离培养物中神经元和神经胶质细胞的存活及/或分化。在主动回避训练的小鼠脑内进行试验后脑池内注射可减轻失忆并增强长期记忆。通过将受损神经组织的退行性变化降至最低并促进可塑性变化，DHEA和DHEAS可能可用于治疗人类神经退行性疾病和记忆障碍。
