Flood J F, Roberts E
Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Hospital, Sepulveda, CA 91343.
Brain Res. 1988 May 10;448(1):178-81. doi: 10.1016/0006-8993(88)91116-x.
Middle-aged (18 month old) and old (24 month old) mice showed poorer retention of footshock active avoidance training (FAAT) than young mice (2 month old). Immediate post-training subcutaneous injection of dehydroepiandrosterone sulfate (DHEAS) improved retention of FAAT in middle-aged and old mice to the high levels observed in young mice. DHEAS, a major naturally occurring adrenal steroid that decreases in blood serum with age, could be rate-limiting in achievement of retention of learning.
中年（18个月大）和老年（24个月大）小鼠在足部电击主动回避训练（FAAT）中的记忆保持能力比幼年小鼠（2个月大）差。训练后立即皮下注射硫酸脱氢表雄酮（DHEAS）可使中年和老年小鼠的FAAT记忆保持能力提高到幼年小鼠所观察到的高水平。DHEAS是一种主要的天然肾上腺类固醇，其血清水平会随着年龄增长而下降，它可能是实现学习记忆保持的限速因素。
