Whitaker John, Tschabrunn Cory M, Jang Jihye, Leshem Eran, O'Neill Mark, Manning Warren J, Anter Elad, Nezafat Reza
Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Division of Imaging Sciences and Biomedical Engineering, King's College, London, UK.
J Magn Reson Imaging. 2018 Mar 9. doi: 10.1002/jmri.26005.
Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias.
We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia-reperfusion-mediated MI.
Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia-reperfusion experimental model of MI.
FIELD STRENGTH/SEQUENCES: 1.5T Philips Achieva scanner. Serial cardiac MRI was performed at 16, 33, and 62 days post-MI, including cine imaging, native and postcontrast T , T and dark-blood late gadolinium enhanced (DB-LGE) scar imaging.
Regions of interest were selected on the parametric maps to assess native T and T in the infarct and in remote tissue. Volume of enhanced tissue, nonenhanced tissue, and gray zone were assessed from DB-LGE imaging. Volumes, cardiac function, and strain were calculated from cine imaging.
Parameters estimated at more than two timepoints were compared with a one-way repeated measures analysis of variance. Parametric mapping data were analyzed using a generalized linear mixed model corrected for multiple observations. A result was considered statistically significant at P < 0.05.
All animals developed anteroseptal akinesia and hyperenhancement on DB-LGE with a central core of nonenhancing tissue. Mean hyperenhancement volume did not change during the observation period, while the central core contracted from 2.2 ± 1.8 ml at 16 days to 0.08 ± 0.19 ml at 62 days (P = 0.008). Native T of ischemic myocardium increased from 1173 ± 93 msec at 16 days to 1309 ± 97 msec at 62 days (P < 0.001). Mean radial and circumferential strain rate magnitude in remote myocardium increased with time from the infarct (P < 0.05).
In this swine model of MI, serial quantitative cardiac MR exams allow characterization of LV remodeling and scar formation.
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
心肌梗死（MI）幸存者有发生包括心力衰竭和恶性心律失常在内的并发症的风险。
我们对心肌梗死后的猪进行了系列成像，目的是在缺血再灌注介导的心肌梗死的转化模型中描述左心室（LV）的纵向重塑。
八只约克夏猪接受左前降支冠状动脉中段球囊闭塞，以创建心肌梗死的缺血再灌注实验模型。
场强/序列：1.5T飞利浦Achieva扫描仪。在心肌梗死后16、33和62天进行系列心脏磁共振成像，包括电影成像、平扫及增强T1、T2和黑血晚期钆增强（DB-LGE）瘢痕成像。
在参数图上选择感兴趣区域，以评估梗死区和远隔组织的平扫T1和T2。从DB-LGE成像评估增强组织、非增强组织和灰色区域的体积。从电影成像计算体积、心脏功能和应变。
对在两个以上时间点估计的参数进行单向重复测量方差分析。使用针对多个观察值校正的广义线性混合模型分析参数映射数据。P < 0.05时结果被认为具有统计学意义。
所有动物均出现前间隔运动减弱和DB-LGE上的强化，有一个无强化组织的中心核心。在观察期内平均强化体积未改变，而中心核心从16天时的2.2±1.8 ml收缩至62天时的0.08±0.19 ml（P = 0.008）。缺血心肌的平扫T1从16天时的1173±93毫秒增加到62天时的1309±97毫秒（P < 0.001）。远隔心肌的平均径向和周向应变率大小随距梗死时间的增加而增加（P < 0.05）。
在这个心肌梗死猪模型中，系列定量心脏磁共振检查可描述左心室重塑和瘢痕形成。
2 技术效能：2期 J.Magn.Reson.Imaging 2018。
