Kim Jae Bong, Jeon Hyeon Jun, Lee Jeong Woo, Choi Kang Young, Chung Ho Yun, Cho Byung Chae, Park Shin-Hyung, Park Min Hee, Bae Jae-Sung, Yang Jung Dug
a Departments of Plastic and Reconstructive Surgery, School of Medicine , Kyungpook National University , Daegu , Korea.
b Department of Radiation Oncology, School of Medicine , Kyungpook National University , Daegu , Korea.
J Plast Surg Hand Surg. 2018 Aug;52(4):217-224. doi: 10.1080/2000656X.2018.1444617. Epub 2018 Mar 9.
As the availability of breast reconstruction using implants is becoming widespread and many implant recipients undergo radiation therapy, there is an increasing interest in understanding the potential complications associated with capsule-tissue interactions in response to irradiation. Accordingly, our medical institution designed an animal experiment to investigate the effects of irradiation on capsular contracture. A total of 40 mice (C57BL6) were divided into four groups according to whether or not they received irradiation and the time from implantation to irradiation. After each mouse received a specially-fabricated, 1.5 cm semi-spherical silicone implant inserted into the area below the panniculus carnosus, half of the mice were irradiated using singe administration of a 10 Gy dose of radiation (6 MeV). Subsequently, data from gross inspection, histological analysis and immunohistochemical analysis were obtained at one and three months postoperatively and analyzed. Changes that occurred near the capsule led to the phenomenon of contracture subsequent to encapsulation. Our findings suggest that the inflammation reaction occurring near the implant becomes aggravated by 'radiation toxicity' and creates an environment conducive to capsular contracture. The present study demonstrated the process by which the complication of capsular contracture may occur during the treatment of human breast cancer via radiotherapy. These findings may serve as the basis for research and development of future treatments of capsular contracture.
随着使用植入物进行乳房重建的方法日益普及，许多接受植入物的患者会接受放射治疗，因此人们越来越关注了解与照射后包膜-组织相互作用相关的潜在并发症。据此，我们的医疗机构设计了一项动物实验来研究照射对包膜挛缩的影响。总共40只小鼠（C57BL6）根据是否接受照射以及从植入到照射的时间分为四组。每只小鼠在腹直肌下区域植入特制的1.5厘米半球形硅胶植入物后，一半小鼠接受单次10 Gy剂量（6 MeV）的放射治疗。随后，在术后1个月和3个月获取大体检查、组织学分析和免疫组织化学分析的数据并进行分析。包膜附近发生的变化导致包膜形成后出现挛缩现象。我们的研究结果表明，植入物附近发生的炎症反应因“辐射毒性”而加剧，并创造了有利于包膜挛缩的环境。本研究证明了在人类乳腺癌放疗治疗过程中可能发生包膜挛缩并发症的过程。这些发现可能为未来包膜挛缩治疗的研发提供依据。
