Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China; College of Bioresources Chemistry and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, PR China; State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Anal Chim Acta. 2018 Jul 19;1014:91-99. doi: 10.1016/j.aca.2018.02.006. Epub 2018 Feb 10.
A two-photon fluorescent probe for Cu and S has been strategically prepared with naphthalimide derivative platform (NPE) covalently grafted onto the surface of magnetic core-shell FeO@SiO nanoparticles. The probe (NPE-FeO@SiO) exhibits selective response to Cu with enhanced fluorescence and efficient separation of Cu with external magnetic field. The consequent product NPE-FeO@SiO-Cu of NPE-FeO@SiO and Cu can work as an excellent sensor for S by removing Cu from the complex with fluorescence decreased, recovering the fluorescence of the probe. Therefore, the constituted Off-On-Off type fluorescence monitoring system means the probe is resumable. Moreover, the probe has been used to quantitatively detect Cu and S with low detection limits, which are 0.28 μM and 0.12 μM, respectively. Furthermore, the probe shows low cytotoxicity and excellent membrane permeability, which has been successfully applied for monitoring Cu and S in living cells and imaging Cu in deep-tissue with two-photon excited fluorescence.
一种基于萘酰亚胺衍生物平台（NPE）的双光子荧光探针已被成功制备，该探针通过共价键接枝到磁性核壳 FeO@SiO 纳米粒子的表面。探针（NPE-FeO@SiO）对 Cu 具有选择性响应，荧光增强，并可在外加磁场下有效分离 Cu。随后，NPE-FeO@SiO 与 Cu 的产物 NPE-FeO@SiO-Cu 可以通过从复合物中去除 Cu 来作为 S 的优异传感器，荧光降低，探针的荧光恢复。因此，所构成的关-开-关型荧光监测系统意味着该探针是可恢复的。此外，该探针已用于定量检测 Cu 和 S，检测限分别低至 0.28 μM 和 0.12 μM。此外，该探针具有低细胞毒性和优异的膜通透性，已成功应用于活细胞中 Cu 和 S 的监测以及利用双光子激发荧光对深层组织中 Cu 的成像。
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