使用锝-六甲基丙二胺肟（Tc-HMPAO）通过动态胸部平面成像评估输入函数对大鼠脑血流量进行无创定量分析。
Noninvasive quantitation of rat cerebral blood flow using Tc-HMPAO-assessment of input function with dynamic chest planar imaging.
作者信息
Suzuki Chie, Kosugi Mutsumi, Magata Yasuhiro
机构信息
Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
出版信息
EJNMMI Res. 2018 Mar 9;8(1):21. doi: 10.1186/s13550-018-0375-7.
BACKGROUND
Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (Tc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampling, to estimate the input function and establish noninvasive quantitation method of rat CBF using the image-derived input function.
RESULTS
Integrated radioactivity concentration in the heart-blood pool on planar images (AUC-planar) was identical to that in arterial blood samples (AUC-sampling). Radioactivity concentration in the brain determined by SPECT imaging (C-SPECT) was identical to that using brain sampling (C-sampling). Noninvasively calculated CBF obtained by dividing C-SPECT by AUC-planar was well correlated with conventionally estimated CBF obtained by dividing C-sampling by AUC-sampling.
CONCLUSION
Rat CBF could be noninvasively quantitated using Tc-HMPAO chest dynamic planar imaging and head SPECT imaging without arterial blood sampling.
背景
使用锝-99m六甲基丙烯胺肟（Tc-HMPAO）定量脑血流量（CBF）通常需要通过动脉血采样来评估输入函数，这对小动物来说具有侵入性。因此，我们进行了胸部动态平面成像，而非动脉血采样，以估计输入函数，并使用图像衍生的输入函数建立大鼠CBF的非侵入性定量方法。
结果
平面图像上心-血池的放射性活度积分浓度（AUC-平面）与动脉血样本中的相同（AUC-采样）。通过SPECT成像测定的脑内放射性活度浓度（C-SPECT）与脑采样法测得的相同（C-采样）。通过将C-SPECT除以AUC-平面得到的非侵入性计算的CBF与通过将C-采样除以AUC-采样得到的传统估计的CBF具有良好的相关性。
结论
无需动脉血采样，使用Tc-HMPAO胸部动态平面成像和头部SPECT成像即可对大鼠CBF进行非侵入性定量。
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