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胰岛素治疗的1型和2型糖尿病患者对低血糖的看法:中东欧国家HAT观察性研究结果

Perspectives of Patients with Insulin-Treated Type 1 and Type 2 Diabetes on Hypoglycemia: Results of the HAT Observational Study in Central and Eastern European Countries.

作者信息

Haluzik Martin, Kretowski Adam, Strojek Krzysztof, Czupryniak Leszek, Janez Andrej, Kempler Peter, Andel Michal, Tankova Tsvetalina, Boyanov Mihail, Smircic Duvnjak Lea, Madacsy Laszlo, Tarnowska Iwona, Zychma Marcin, Lalic Nebojsa

机构信息

Diabetes Centre and Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21, Prague 4, Czech Republic.

Department of Endocrinology, Diabetology and Internal Diseases, Medical University of Białystok, Białystok, Poland.

出版信息

Diabetes Ther. 2018 Apr;9(2):727-741. doi: 10.1007/s13300-018-0388-2. Epub 2018 Mar 9.

Abstract

INTRODUCTION

The aim of this study was to determine the level of awareness of hypoglycemia, the level of fear for hypoglycemia, and the response to hypoglycemic events among insulin-treated diabetes patients from Central and Eastern Europe (CEE). The impact of hypoglycemia on the use of healthcare resources and patient productivity was also assessed.

METHODS

This was a multicenter, non-interventional, two-part, patient self-reported questionnaire study that comprised both a retrospective cross-sectional evaluation and a prospective observational evaluation. Study participants were insulin-treated adult patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) from CEE.

RESULTS

Most patients (85.4% T1DM and 83.6% T2DM) reported normal hypoglycemia awareness. The median hypoglycemia fear score was 5 out of 10 for T1DM and 4 out of 10 for T2DM patients. Patients increased glucose monitoring, consulted a doctor/nurse, and/or reduced the insulin dose in response to hypoglycemia. As a consequence of hypoglycemia, patients took leave from work/studies or arrived late and/or left early. Hospitalization was required for 31 (1.2%) patients with T1DM and 66 (2.1%) patients with T2DM.

CONCLUSION

Hypoglycemia impacts patients' personal and social functioning, reduces productivity, and results in additional costs, both direct (related to increased use of healthcare resources) and indirect (related to absenteeism.

FUNDING

Novo Nordisk.

摘要

引言

本研究旨在确定中东欧胰岛素治疗糖尿病患者对低血糖的认知水平、对低血糖的恐惧程度以及对低血糖事件的应对情况。同时评估低血糖对医疗资源使用和患者生产力的影响。

方法

这是一项多中心、非干预性、分两部分的患者自我报告问卷调查研究,包括回顾性横断面评估和前瞻性观察评估。研究参与者为中东欧接受胰岛素治疗的1型糖尿病(T1DM)或2型糖尿病(T2DM)成年患者。

结果

大多数患者(T1DM患者为85.4%,T2DM患者为83.6%)报告低血糖认知正常。T1DM患者低血糖恐惧评分中位数为10分中的5分,T2DM患者为10分中的4分。患者因低血糖增加血糖监测、咨询医生/护士和/或减少胰岛素剂量。低血糖导致患者请假不上班/不上学、迟到和/或早退。31例(1.2%)T1DM患者和66例(2.1%)T2DM患者需要住院治疗。

结论

低血糖会影响患者的个人和社会功能,降低生产力,并导致直接(与医疗资源使用增加有关)和间接(与旷工有关)的额外成本。

资助

诺和诺德公司。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2361/6104285/98a4a484dbb0/13300_2018_388_Fig1_HTML.jpg

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