Strandberg Ragnhild B, Graue Marit, Wentzel-Larsen Tore, Peyrot Mark, Wahl Astrid K, Rokne Berit
Centre for Evidence Based Practice, Bergen University College, Bergen, Norway; Department of Global Public Health and Primary Care, the Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Centre for Evidence Based Practice, Bergen University College, Bergen, Norway; Department of Paediatrics, Haukeland University Hospital, Bergen, Norway.
Diabetes Res Clin Pract. 2017 Feb;124:11-19. doi: 10.1016/j.diabres.2016.12.018. Epub 2016 Dec 27.
To examine the associations among fear of hypoglycaemia, diabetes-related quality of life and psychological well-being, and determine whether diabetes-related quality of life is a mediator of the relationship between fear of hypoglycaemia and psychological well-being in adults with Type 1 diabetes.
A total of 235 of 319 invited adults (18-69years) with Type 1 diabetes agreed to participate. Hierarchical linear regression was applied to 188 individuals with complete data. Mediation analysis was used to determine whether diabetes-related quality of life mediated the relationship between fear of hypoglycaemia and psychological well-being.
Fear of hypoglycaemia was significantly associated with diabetes-related quality of life and psychological well-being. The behaviour and worry components of fear of hypoglycaemia were significantly associated with diabetes-related quality of life (behaviour component: unstandardised coefficient=-0.04, p<0.001, standardised coefficient=-0.40; worry component: unstandardised coefficient=-0.01, p=0.041, standardised coefficient=-0.18). Fear of hypoglycaemia worry had a significant independent association with psychological well-being (unstandardised coefficient=-0.28, p=0.009, standardised coefficient=-0.25), whereas fear of hypoglycaemia behaviour did not. Diabetes-related quality of life mediated approximately half of the association between fear of hypoglycaemia worry and psychological well-being.
Hypoglycaemic episodes can have serious consequences, and assessing fear of hypoglycaemia might help health care providers offer suitable care strategies to individuals with Type 1 diabetes.
探讨低血糖恐惧、糖尿病相关生活质量与心理健康之间的关联，并确定糖尿病相关生活质量是否为1型糖尿病成年人低血糖恐惧与心理健康之间关系的中介因素。
在319名受邀的18 - 69岁1型糖尿病成年人中，共有235人同意参与。对188名有完整数据的个体进行分层线性回归分析。采用中介分析来确定糖尿病相关生活质量是否介导了低血糖恐惧与心理健康之间的关系。
低血糖恐惧与糖尿病相关生活质量及心理健康显著相关。低血糖恐惧的行为和担忧成分与糖尿病相关生活质量显著相关（行为成分：非标准化系数 = -0.04，p < 0.001，标准化系数 = -0.40；担忧成分：非标准化系数 = -0.01，p = 0.041，标准化系数 = -0.18）。低血糖恐惧担忧与心理健康有显著的独立关联（非标准化系数 = -0.28，p = 0.009，标准化系数 = -0.25），而低血糖恐惧行为则不然。糖尿病相关生活质量介导了低血糖恐惧担忧与心理健康之间约一半的关联。
低血糖发作可能会产生严重后果，评估低血糖恐惧可能有助于医护人员为1型糖尿病患者提供合适的护理策略。
