Wang Yirong, Zhao Pingping, Zhao Yang Ting, Chen Chongyang, Lv Xiaoyu, Wang Liting, Gao Jie, Liu Jingfang
The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, Gansu, China.
Asia Pac J Clin Nutr. 2025 Jun;34(3):411-419. doi: 10.6133/apjcn.202506_34(3).0015.
To investigate the correlation between weight-adjusted-waist index (WWI), a novel obesity index, and serum ferritin (SF) level in patients with type 2 diabetes mellitus (T2DM), and the association between WWI and the prevalence of hyperferritinemia.
A total of 943 patients with T2DM were divided into three groups based on WWI tertile levels. Disparities in SF levels and the prevalence of hyperferritinemia were compared among these groups. The correlations among WWI, SF levels, and hyperferritinemia were analyzed in patients with T2DM.
As WWI tertile levels increased, SF levels tended to increase (p for trend <0.01). A statistically significant positive correlation was observed between the WWI and SF levels (R = 0.263, p < 0.001). After adjusting for confounders by multiple linear regression, a significant positive correlation was maintained between the WWI and SF levels [β = 0.194, 95% CI (49.914, 112.120)], p < 0.01]. Binary logistic regression analysis revealed a positive association between the WWI and the likelihood of hyperferritinemia, with a notably stronger correlation observed in females compared to males [OR = 3.248, 95% CI (2.027, 5.204), p < 0.01 vs. OR = 2.091, 95% CI (1.432, 3.054), p < 0.01].
Along with increasing WWI, SF levels gradually increased in patients with T2DM. The WWI exhibited a positive correlation with SF levels and hyperferritinemia, more significantly in female patients.
探讨新型肥胖指数——体重校正腰围指数（WWI）与2型糖尿病（T2DM）患者血清铁蛋白（SF）水平之间的相关性，以及WWI与高铁蛋白血症患病率之间的关联。
根据WWI三分位数水平将943例T2DM患者分为三组。比较这些组之间SF水平和高铁蛋白血症患病率的差异。分析T2DM患者中WWI、SF水平和高铁蛋白血症之间的相关性。
随着WWI三分位数水平升高，SF水平呈上升趋势（趋势p<0.01）。WWI与SF水平之间存在统计学显著正相关（R = 0.263，p < 0.001）。通过多元线性回归校正混杂因素后，WWI与SF水平之间仍保持显著正相关[β = 0.194，95%CI（49.914，112.120）]，p < 0.01]。二元逻辑回归分析显示，WWI与高铁蛋白血症的可能性呈正相关，女性的相关性明显强于男性[比值比（OR）= 3.248，95%CI（2.027，5.204），p < 0.01 vs. OR = 2.091，95%CI（1.432，3.054），p < 0.01]。
在T2DM患者中，随着WWI升高，SF水平逐渐升高。WWI与SF水平及高铁蛋白血症呈正相关，在女性患者中更显著。
