Clinical Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Mult Scler Relat Disord. 2018 May;22:35-37. doi: 10.1016/j.msard.2018.02.023. Epub 2018 Feb 22.
Acquired demyelinating CNS syndromes include a broad spectrum of clinical phenotypes and different entities can overlap. Therefore, differential diagnosis is still challenging. A humoral immune reaction against myelin oligodendrocyte glycoprotein (MOG) is present in a subgroup of these patients, particularly in children. Anti-MOG antibodies indicate a non-multiple sclerosis disease course. Indeed, early publications have suggested that anti-MOG antibodies argue for a monophasic course; recently an association with a high risk for recurrent non-MS disease has been shown. According new data, antibody analysis was included in a diagnostic algorithm for the diagnosis of acquired demyelinating CNS syndromes in children. Here, recent data from the implementation of anti-MOG antibodies in daily clinical practice are reviewed.
获得性中枢神经系统脱髓鞘综合征包括广泛的临床表型，不同的疾病实体可能会重叠。因此，鉴别诊断仍然具有挑战性。这些患者中有一部分存在针对髓鞘少突胶质细胞糖蛋白（MOG）的体液免疫反应，特别是在儿童中。抗 MOG 抗体表明疾病过程是非多发性硬化。事实上，早期的出版物表明，抗 MOG 抗体表明单相病程；最近，有研究表明其与多发性硬化症复发的高风险相关。根据新的数据，抗体分析已被纳入儿童获得性中枢神经系统脱髓鞘综合征的诊断算法中。在此，对抗体分析在日常临床实践中的应用的最新数据进行综述。
