Shaare Zedek Medical Center, Jerusalem, Israel.
Shaare Zedek Medical Center, Jerusalem, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Pediatr. 2018 Jul;198:304-307. doi: 10.1016/j.jpeds.2018.01.024. Epub 2018 Mar 7.
We determined serum paracetamol concentrations 4 hours after the eighth dose in infants treated enterally for ductal closure. Serum paracetamol concentrations correlated (P = .0026) with ductal response. No patent ductus arteriosus in a baby with paracetamol levels <20 mg/L closed in response to treatment. Paracetamol levels also correlated (P = .046) with postnatal age.
我们测定了经肠道给药行导管闭合术的婴儿第八次给药后 4 小时的血清对乙酰氨基酚浓度。血清对乙酰氨基酚浓度与（P=0.0026）导管反应相关。血清对乙酰氨基酚浓度<20mg/L 的婴儿对治疗有反应，其动脉导管未闭（patent ductus arteriosus，PDA）未闭。对乙酰氨基酚水平也与（P=0.046）出生后年龄相关。
