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动脉导管未闭封堵术中对乙酰氨基酚的有效性、安全性及血药浓度监测：病例系列

Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series.

作者信息

Kessel Irena, Waisman Dan, Lavie-Nevo Karen, Golzman Marcelo, Lorber Avraham, Rotschild Avi

机构信息

Department of Neonatology, Carmel Medical Center , Haifa, Israel .

出版信息

J Matern Fetal Neonatal Med. 2014 Nov;27(16):1719-21. doi: 10.3109/14767058.2013.871630. Epub 2014 Feb 7.

DOI:10.3109/14767058.2013.871630
PMID:24460433
Abstract

Paracetamol was reported to be effective for patent ductus arteriosus (PDA) closure. We present a case series of PDA closure by paracetamol in seven premature infants. During the treatment, paracetamol blood levels did not exceed the recommended levels for analgesia and hyperthermia in six tested infants. None of the patients demonstrated significant disturbances of liver function.

摘要

据报道，对乙酰氨基酚对动脉导管未闭（PDA）闭合有效。我们展示了一组7例早产儿使用对乙酰氨基酚闭合PDA的病例系列。在治疗过程中，6例接受检测的婴儿的对乙酰氨基酚血药浓度未超过镇痛和退热的推荐水平。所有患者均未出现明显的肝功能紊乱。

相似文献

1
Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series.动脉导管未闭封堵术中对乙酰氨基酚的有效性、安全性及血药浓度监测：病例系列
J Matern Fetal Neonatal Med. 2014 Nov;27(16):1719-21. doi: 10.3109/14767058.2013.871630. Epub 2014 Feb 7.
2
Paracetamol Serum Concentrations in Neonates Treated Enterally for Ductal Closure: A Pilot Study.经肠道给予对乙酰氨基酚治疗新生儿导管闭合：一项初步研究。
J Pediatr. 2018 Jul;198:304-307. doi: 10.1016/j.jpeds.2018.01.024. Epub 2018 Mar 7.
3
A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol.动脉导管未闭药物治疗中的一种不同的首选药物：口服对乙酰氨基酚。
J Matern Fetal Neonatal Med. 2013 May;26(8):825-7. doi: 10.3109/14767058.2012.755162. Epub 2013 Jan 15.
4
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.一种用于对布洛芬耐药或禁忌的早产儿动脉导管未闭管理的替代药物（对乙酰氨基酚）。
Arch Dis Child Fetal Neonatal Ed. 2013 Jan;98(1):F94. doi: 10.1136/archdischild-2012-302044. Epub 2012 May 18.
5
Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure.静脉注射对乙酰氨基酚对布洛芬有禁忌或布洛芬治疗失败的极低出生体重儿动脉导管未闭的作用有限。
Eur J Pediatr. 2015 Nov;174(11):1433-40. doi: 10.1007/s00431-015-2541-5. Epub 2015 Apr 30.
6
Paracetamol to induce ductus arteriosus closure: is it valid?对乙酰氨基酚诱导动脉导管关闭：有效吗？
Arch Dis Child. 2013 Jun;98(6):462-6. doi: 10.1136/archdischild-2013-303688. Epub 2013 Apr 20.
7
Ductal closure with intravenous paracetamol: a new approach to patent ductus arteriosus treatment.静脉注射对乙酰氨基酚实现导管闭合：动脉导管未闭治疗的新方法。
J Matern Fetal Neonatal Med. 2016 Mar;29(6):987-90. doi: 10.3109/14767058.2015.1029912. Epub 2015 Apr 2.
8
Intravenous paracetamol with a lower dose is also effective for the treatment of patent ductus arteriosus in pre-term infants.低剂量静脉注射对乙酰氨基酚对治疗早产儿动脉导管未闭也有效。
Cardiol Young. 2015 Aug;25(6):1060-4. doi: 10.1017/S1047951114001577. Epub 2014 Aug 27.
9
Paracetamol therapy for patent ductus arteriosus in premature infants: a chance before surgical ligation.对早产儿动脉导管未闭采用对乙酰氨基酚治疗：手术结扎前的一次机会。
Pediatr Cardiol. 2014 Feb;35(2):276-9. doi: 10.1007/s00246-013-0770-9. Epub 2013 Aug 13.
10
Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: study protocol for a randomized control trial.静脉注射对乙酰氨基酚与布洛芬治疗早产儿动脉导管未闭的疗效和安全性比较：一项随机对照试验的研究方案
Trials. 2016 Apr 2;17:182. doi: 10.1186/s13063-016-1294-4.

引用本文的文献

1
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.对早产儿或低出生体重儿的动脉导管未闭（patent ductus arteriosus），使用扑热息痛（acetaminophen，对乙酰氨基酚）。
Cochrane Database Syst Rev. 2022 Dec 15;12:CD010061. doi: 10.1002/14651858.CD010061.pub5.
2
Different approaches for patent ductus arteriosus in premature infants using acetaminophen.使用对乙酰氨基酚治疗早产儿动脉导管未闭的不同方法。
World J Pediatr. 2022 Apr;18(4):243-250. doi: 10.1007/s12519-022-00526-4. Epub 2022 Mar 6.
3
Paracetamol (acetaminophen) use in infants and children was never shown to be safe for neurodevelopment: a systematic review with citation tracking.
对婴儿和儿童使用扑热息痛（对乙酰氨基酚）从未被证明对神经发育是安全的：一项有引文追踪的系统评价。
Eur J Pediatr. 2022 May;181(5):1835-1857. doi: 10.1007/s00431-022-04407-w. Epub 2022 Feb 17.
4
Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?对乙酰氨基酚与发育中的肺：会有终身影响吗？
J Pediatr. 2021 Aug;235:264-276.e1. doi: 10.1016/j.jpeds.2021.02.026. Epub 2021 Feb 20.
5
Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?高剂量静脉用对乙酰氨基酚是否会影响早产儿动脉导管未闭关闭时的肝功能？
Ital J Pediatr. 2021 Feb 18;47(1):37. doi: 10.1186/s13052-020-00940-2.
6
Maternal paracetamol intake and fetal ductus arteriosus constriction/closure: comprehensive signal evaluation using the Austin Bradford Hill criteria.母亲对扑热息痛的摄入与胎儿动脉导管收缩/闭锁：使用奥斯汀·布拉德福德·希尔标准进行综合信号评估。
Eur J Clin Pharmacol. 2021 Jul;77(7):1019-1028. doi: 10.1007/s00228-020-03039-z. Epub 2021 Jan 7.
7
Paracetamol vs. Ibuprofen in Preterm Infants With Hemodynamically Significant Patent Ductus Arteriosus: A Non-inferiority Randomized Clinical Trial Protocol.对血流动力学显著的动脉导管未闭早产儿使用对乙酰氨基酚与布洛芬的比较：一项非劣效性随机临床试验方案
Front Pediatr. 2020 Jul 17;8:372. doi: 10.3389/fped.2020.00372. eCollection 2020.
8
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.对乙酰氨基酚（醋氨酚）用于早产儿或低出生体重儿动脉导管未闭的治疗。
Cochrane Database Syst Rev. 2020 Jan 27;1(1):CD010061. doi: 10.1002/14651858.CD010061.pub4.
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Early PARacetamol (EPAR) trial: a study protocol for a randomised controlled trial of early paracetamol to promote closure of the ductus arteriosus in preterm infants.早期扑热息痛（EPAR）试验：一项随机对照试验的研究方案，旨在研究早期扑热息痛对早产儿动脉导管未闭闭合的影响。
BMJ Open. 2019 Oct 30;9(10):e031428. doi: 10.1136/bmjopen-2019-031428.
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Diagnosis and Management of Patent Ductus Arteriosus.动脉导管未闭的诊断与管理
Neoreviews. 2018 Jul;19(7):e394-e402. doi: 10.1542/neo.19-7-e394.