Dementia Research Centre, UCL, London, UK.
Department of Neurodegeneration, UCL, London, UK.
Curr Neurol Neurosci Rep. 2018 Mar 10;18(4):17. doi: 10.1007/s11910-018-0823-9.
Mild cognitive impairment is a common feature of Parkinson's disease, even at the earliest disease stages, but there is variation in the nature and severity of cognitive involvement and in the risk of conversion to Parkinson's disease dementia. This review aims to summarise current understanding of mild cognitive impairment in Parkinson's disease. We consider the presentation, rate of conversion to dementia, underlying pathophysiology and potential biomarkers of mild cognitive impairment in Parkinson's disease. Finally, we discuss challenges and controversies of mild cognitive impairment in Parkinson's disease.
Large-scale longitudinal studies have shown that cognitive involvement is important and common in Parkinson's disease and can present early in the disease course. Recent criteria for mild cognitive impairment in Parkinson's provide the basis for further study of cognitive decline and for the progression of different cognitive phenotypes and risk of conversion to dementia. Improved understanding of the underlying pathology and progression of cognitive change are likely to lead to opportunities for early intervention for this important aspect of Parkinson's disease.
轻度认知障碍是帕金森病的一个常见特征，甚至在疾病的早期阶段也是如此，但认知障碍的性质和严重程度以及向帕金森病痴呆的转化风险存在差异。本综述旨在总结目前对帕金森病轻度认知障碍的认识。我们考虑了帕金森病轻度认知障碍的表现、向痴呆的转化率、潜在的病理生理学和潜在的生物标志物。最后，我们讨论了帕金森病轻度认知障碍的挑战和争议。
大规模纵向研究表明，认知障碍在帕金森病中很重要且常见，并且可能在疾病早期就出现。帕金森病轻度认知障碍的最新标准为进一步研究认知下降以及不同认知表型的进展和向痴呆的转化风险提供了基础。对潜在病理和认知变化进展的认识的提高，可能为帕金森病这一重要方面的早期干预提供机会。
