Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Mov Disord. 2019 Mar;34(3):430-435. doi: 10.1002/mds.27617. Epub 2019 Jan 17.
The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.
We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia.
Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia.
Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.
国际帕金森病和运动障碍学会（International Parkinson and Movement Disorders Society，简称 IPAD）制定的 PD 轻度认知障碍（mild cognitive impairment，MCI）标准需要验证。本研究旨在评估 PD 痴呆发展的 I 级（简略）MCI 标准的预后价值，并将其与 II 级（全面）标准进行比较。
我们分析了来自我们联盟的 8 项国际研究（1045 名患者）的数据，这些研究包括人口统计学、运动症状、抑郁、详细的神经心理学测试以及向帕金森病痴呆转化的纵向随访的基线数据。生存分析评估了它们对帕金森病痴呆风险的贡献。
PD 中的 I 级 MCI、年龄增长、男性性别和 PD 运动症状的严重程度独立增加了帕金森病痴呆的风险。I 级和 II 级 MCI 在 PD 分类中的分类能力在帕金森病痴呆的时间上具有相似的预测能力。
PD 中的 I 级 MCI 分类独立地增加了帕金森病痴呆的风险。这一发现支持简略 MCI 标准在 PD 中的预后价值。©2019 国际帕金森病和运动障碍学会。
