帕金森病痴呆的风险与 I 级 MDS PD-MCI 相关。

Risk of Parkinson's disease dementia related to level I MDS PD-MCI.

机构信息

Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Mov Disord. 2019 Mar;34(3):430-435. doi: 10.1002/mds.27617. Epub 2019 Jan 17.

DOI:10.1002/mds.27617

PMID:30653248

Abstract

BACKGROUND

The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.

METHODS

We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia.

RESULTS

Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia.

CONCLUSIONS

Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.

摘要

背景

国际帕金森病和运动障碍学会（International Parkinson and Movement Disorders Society，简称 IPAD）制定的 PD 轻度认知障碍（mild cognitive impairment，MCI）标准需要验证。本研究旨在评估 PD 痴呆发展的 I 级（简略）MCI 标准的预后价值，并将其与 II 级（全面）标准进行比较。