自然杀伤细胞与IgE在控制人类持续IgE合成中的相互作用。
Natural killer cell interaction with IgE in the control of ongoing human IgE synthesis.
作者信息
Kimata H, Saxon A
出版信息
Int Arch Allergy Appl Immunol. 1987;82(3-4):419-21. doi: 10.1159/000234244.
Fresh natural killer (NK) cells from normal donors inhibited IgE synthesis from U266/AF-10 cells via a direct cytolytic effect. This inhibition was 'reversed' by incubation of NK cells with human IgE-anti-IgE immune complexes (IgE-IC) for 16 h without a decrease in NK-mediated cytotoxicity. Upon incubation with IgE-IC, Fc epsilon receptors (FcER) were induced on 3-9% of NK cells. These IgE-IC induced FcER+ NK cells from normal donors secreted (an) IgE-specific factor(s) which enhanced U266/AF-10 IgE production without increasing DNA synthesis. Production of this IgE differentiation factor(s) explains the apparent reversal of NK cell inhibition of IgE production.
来自正常供体的新鲜自然杀伤（NK）细胞通过直接细胞溶解作用抑制U266/AF-10细胞合成IgE。将NK细胞与人IgE-抗IgE免疫复合物（IgE-IC）孵育16小时后，这种抑制作用“被逆转”，且NK介导的细胞毒性并未降低。与IgE-IC孵育后，3%-9%的NK细胞诱导产生了Fcε受体（FcER）。这些由IgE-IC诱导产生FcER的正常供体NK细胞分泌一种IgE特异性因子，该因子可增强U266/AF-10细胞的IgE产生，但不增加DNA合成。这种IgE分化因子的产生解释了NK细胞对IgE产生抑制作用明显逆转的现象。
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