Division of Cancer and Stem Cells, Faculty of Medicine, University of Nottingham, United Kingdom.
Department of Microbiology and Immunology and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA.
Semin Oncol. 2017 Aug;44(4):288-300. doi: 10.1053/j.seminoncol.2017.10.012. Epub 2018 Jan 19.
Inflammatory breast cancer (IBC) in humans is the most aggressive form of mammary gland cancer and shares clinical, pathologic, and molecular patterns of disease with canine inflammatory mammary carcinoma (CIMC). Despite the use of multimodal therapeutic approaches, including targeted therapies, the prognosis for IBC/CIMC remains poor. The aim of this review is to critically analyze IBC and CIMC in terms of biology and clinical features. While rodent cancer models have formed the basis of our understanding of cancer biology, the translation of this knowledge into improved outcomes has been limited. However, it is possible that a comparative "one health" approach to research, using a natural canine model of the disease, may help advance our knowledge on the biology of the disease. This will translate into better clinical outcomes for both species. We propose that CIMC has the potential to be a useful model for developing and testing novel therapies for IBC. Further, this strategy could significantly improve and accelerate the design and establishment of new clinical trials to identify novel and improved therapies for this devastating disease in a more predictable way.
人炎性乳腺癌（IBC）是乳腺恶性肿瘤中侵袭性最强的一种，在临床、病理和疾病分子模式上与犬炎性乳腺癌（CIMC）相似。尽管采用了包括靶向治疗在内的多种治疗方法，IBC/CIMC 的预后仍然很差。本文旨在从生物学和临床特征方面对 IBC 和 CIMC 进行批判性分析。虽然啮齿动物癌症模型是我们理解癌症生物学的基础，但将这些知识转化为改善预后的效果有限。然而，使用疾病的自然犬模型进行比较“同一健康”研究方法，可能有助于提高我们对疾病生物学的认识。这将转化为两种物种更好的临床结果。我们提出 CIMC 有可能成为开发和测试 IBC 新型疗法的有用模型。此外，这种策略可以显著改善和加速设计和建立新的临床试验，以更可预测的方式为这种毁灭性疾病确定新的和改进的治疗方法。
