Universidade Federal de Mato Grosso (UFMT), Faculdade de Medicina, Departamento de Pediatria, Cuiabá, MT, Brazil.
Universidade Federal de Mato Grosso (UFMT), Faculdade de Medicina, Departamento de Clínica Médica, Cuiabá, MT, Brazil.
J Pediatr (Rio J). 2019 Mar-Apr;95(2):173-179. doi: 10.1016/j.jped.2018.01.003. Epub 2018 Mar 9.
To determine decision limits for total cholesterol, LDL-cholesterol, non-HDL cholesterol, HDL-cholesterol, and triglycerides in healthy children and adolescents from Cuiabá, Brazil.
This was a cross-sectional study of 1866 healthy children and adolescents randomly selected from daycare centers and public schools in Cuiabá. The desirable levels of serum lipids were defined using the classic criteria, i.e., total cholesterol, LDL-cholesterol, non-HDL cholesterol, and triglycerides levels below the P75 percentile, and HDL-c above the P10 percentile.
For CT, P75 was: 160mg/dL for the age range of 1 to <3 years, 170mg/dL for ≥3 to <9 years, and 176mg/dL for ≥9 to <13 years. For non-HDL cholesterol, it was 122mg/dL for the age range of 1 to <13 years. For LDL-c, it was 104mg/dL at the age range of 1 to <9 years and 106mg/dL from ≥9 to <13 years. For TG, it was 127mg/dL from 1 to <2 years; 98mg/dL from ≥2 to <6 years; and 92mg/dL from ≥6 to <13 years. As for HDL-cholesterol, P10 was 24mg/dL, 28mg/dL, 32mg/dL, and 36mg/dL, for the age ranges of 1 to <2 years, ≥2 to <3 years, ≥3 to <4 years, and ≥4 to <13 years, respectively.
The decision limits for the serum lipid levels defined in this study differed from those observed in the current Brazilian and North-American guidelines, especially because it differentiates between the age ranges. Using these decision limits in clinical practice will certainly contribute to improve the diagnostic accuracy for dyslipidemia in this population group.
确定巴西库亚巴市健康儿童和青少年总胆固醇、低密度脂蛋白胆固醇、非高密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的决策限值。
这是一项横断面研究，共纳入 1866 名随机选自库亚巴市日托中心和公立学校的健康儿童和青少年。血清脂质的理想水平根据经典标准定义，即总胆固醇、低密度脂蛋白胆固醇、非高密度脂蛋白胆固醇和甘油三酯水平低于第 75 百分位数，高密度脂蛋白胆固醇高于第 10 百分位数。
对于 CT，第 75 个百分位数为：1 至<3 岁为 160mg/dL，3 至<9 岁为 170mg/dL，9 至<13 岁为 176mg/dL。对于非高密度脂蛋白胆固醇，1 至<13 岁的年龄范围为 122mg/dL。对于 LDL-c，1 至<9 岁的年龄范围为 104mg/dL，9 至<13 岁的年龄范围为 106mg/dL。对于 TG，1 至<2 岁为 127mg/dL，2 至<6 岁为 98mg/dL，6 至<13 岁为 92mg/dL。对于高密度脂蛋白胆固醇，P10 分别为 1 至<2 岁时为 24mg/dL，2 至<3 岁时为 28mg/dL，3 至<4 岁时为 32mg/dL，4 至<13 岁时为 36mg/dL。
本研究中定义的血清脂质水平的决策限值与当前巴西和北美指南观察到的限值不同，特别是因为它区分了年龄范围。在临床实践中使用这些决策限值肯定会有助于提高该人群组中血脂异常的诊断准确性。
