Li Panpan, Yin Hexuan, Meng Fanling, Liu Shuang, Liu Haixia, Ma Rong
Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, China.
Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, China.
Pathol Res Pract. 2018 May;214(5):727-731. doi: 10.1016/j.prp.2018.03.007. Epub 2018 Mar 6.
Tripartite motif-containing protein 44 (TRIM44) has been recently identified as a novel oncogene that is overexpressed in several types of human cancers; however, its role in endometrial cancer (EC) remains unknown. The purpose of the current study was to investigate the TRIM44 protein expression and clinicopathological significance of TRIM44 in EC.
Paraffin-embedded surgical specimens were collected from 143 patients with EC for the immunohistochemical analysis of TRIM44 expression. Western blotting was performed to evaluate differences in TRIM44 protein expression in EC and normal endometrial tissues.
TRIM44 expression was low in normal tissues and high in EC tissues (P < 0.001). TRIM44 overexpression was significantly associated with the Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, depth of myometrial invasion and lymph node metastasis (P < 0.05). Moreover, TRIM44 expression was an independent prognostic factor for both overall survival and disease-free survival in patients with EC (both P < 0.05).
The present study provides evidence that TRIM44 predicts the risk of development and prognosis of EC, highlighting its potential application as a therapeutic target for this malignancy.
含三联基序蛋白44（TRIM44）最近被鉴定为一种新型癌基因，在多种人类癌症中过表达；然而，其在子宫内膜癌（EC）中的作用尚不清楚。本研究旨在探讨TRIM44蛋白在EC中的表达及其临床病理意义。
收集143例EC患者的石蜡包埋手术标本，进行TRIM44表达的免疫组织化学分析。采用蛋白质印迹法评估EC组织和正常子宫内膜组织中TRIM44蛋白表达的差异。
TRIM44在正常组织中表达较低，在EC组织中表达较高（P<0.001）。TRIM44过表达与国际妇产科联盟（FIGO）分期、组织学分级、肌层浸润深度和淋巴结转移显著相关（P<0.05）。此外，TRIM44表达是EC患者总生存和无病生存的独立预后因素（均P<0.05）。
本研究提供了证据表明TRIM44可预测EC的发生风险和预后，突出了其作为这种恶性肿瘤治疗靶点的潜在应用价值。
