Shang Pan, Meng Fanling, Liu Yunduo, Chen Xiuwei
Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, 150081, China.
Tumour Biol. 2015 Jun;36(6):4479-85. doi: 10.1007/s13277-015-3089-8. Epub 2015 May 2.
This study aimed to explore the clinical significance of AAA+ (ATPases associated with various cellular activities) nuclear coregulator cancer-associated (ANCCA) protein expression in endometrial carcinoma (EC). Correlations of ANCCA expression with clinicopathological factors and prognosis of EC patients were analyzed. Expression of ANCCA was detected in EC from 207 patients along with corresponding normal endometrium specimens by immunohistochemistry. ANCCA immunoreactivity was overexpressed in EC cases compared with that in normal endometrium (P < 0.001). High ANCCA expression was positively correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, depth of myometrial invasion, lymph node metastasis, lymph vascular space involvement, and recurrence but not with age and histological type. Patients with high ANCCA expression exhibited significantly poorer overall survival (OS) and disease-free survival (DFS) than patients with low ANCCA expression (P = 0.001 and 0.002, respectively). Cox multivariate analysis showed that high ANCCA expression was an independent prognostic factor for both OS (hazard ratio (HR) = 4.954, 95 % confidence interval (CI) = 1.537-15.966; P = 0.007) and DFS of patients with EC (HR = 4.237, 95 % CI = 1.295-13.859; P = 0.017). We identified ANCCA protein expression as a novel independent poor prognostic indicator in EC.
本研究旨在探讨与多种细胞活动相关的ATP酶（AAA+）核共调节因子癌症相关（ANCCA）蛋白表达在子宫内膜癌（EC）中的临床意义。分析了ANCCA表达与EC患者临床病理因素及预后的相关性。采用免疫组织化学法检测了207例EC患者及其相应正常子宫内膜标本中ANCCA的表达。与正常子宫内膜相比，EC病例中ANCCA免疫反应性过表达（P < 0.001）。ANCCA高表达与国际妇产科联盟（FIGO）分期、组织学分级、肌层浸润深度、淋巴结转移、淋巴血管间隙受累及复发呈正相关，但与年龄和组织学类型无关。ANCCA高表达患者的总生存期（OS）和无病生存期（DFS）显著低于ANCCA低表达患者（分别为P = 0.001和0.002）。Cox多因素分析显示，ANCCA高表达是EC患者OS（风险比（HR）= 4.954，95%置信区间（CI）= 1.537 - 15.966；P = 0.007）和DFS的独立预后因素（HR = 4.237，95% CI = 1.295 - 13.859；P = 0.017）。我们确定ANCCA蛋白表达是EC中一种新的独立不良预后指标。
