Ogawa Mikako, Takakura Hideo
Laboratory for Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University.
JST, PRESTO.
Anal Sci. 2018;34(3):273-281. doi: 10.2116/analsci.34.273.
In vivo molecular imaging is a powerful tool to analyze the human body. Precision medicine is receiving high attention these days, and molecular imaging plays an important role as companion diagnostics in precision medicine. Nuclear imaging with PET or SPECT and optical imaging technologies are used for in vivo molecular imaging. Nuclear imaging is superior for quantitative imaging, and whole-body analysis is possible even for humans. Optical imaging is superior due to its ease of use, and highly targeted specific imaging is possible with activatable agents. However, with optical imaging using fluorescence, it is difficult to obtain a signal from deep tissue and quantitation is difficult due to the attenuation and scattering of the fluorescent signal. Recently, to overcome these issues, optoacoustic imaging has been used in in vivo imaging. In this article, we review in vivo molecular imaging with nuclear and optical imaging and discuss their utility for precision medicine.
体内分子成像是分析人体的强大工具。如今，精准医学备受关注，分子成像作为精准医学中的伴随诊断发挥着重要作用。正电子发射断层显像（PET）或单光子发射计算机断层显像（SPECT）的核成像以及光学成像技术用于体内分子成像。核成像在定量成像方面具有优势，甚至对人体也能进行全身分析。光学成像因其使用简便而具有优势，并且使用可激活剂可以实现高度靶向的特异性成像。然而，对于使用荧光的光学成像，很难从深部组织获得信号，并且由于荧光信号的衰减和散射，定量分析也很困难。最近，为了克服这些问题，光声成像已用于体内成像。在本文中，我们综述了核成像和光学成像的体内分子成像，并讨论了它们在精准医学中的效用。
