Immunology Section, Saylmaniya Medical Center, Manama, Kingdom of Bahrain; Arabian Gulf University, Manama, Kingdom of Bahrain.
Arabian Gulf University, Manama, Kingdom of Bahrain; Paediatrics Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
East Mediterr Health J. 2018 Mar 5;23(12):821-829. doi: 10.26719/2017.23.12.821.
In Bahrain, adequate epidemiological information is lacking concerning the rate of EBV infection, which could be helpful in order to develop measures to protect against EBV infections. The aim of this study, was to investigate the trend of EBV infection in Bahrain over a 15-year period, 2001-2015. The EBV serological results of 10 560 patients with possible EBV infection were evaluated. Samples taken at the Salmaniya Medical Complex during 2001-2015 were included. The presence or absence of EBV viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA) IgG antibodies was recorded. Of the 10 560 samples, 10 333 were usable; of these, 86.1% were seropositive with an increasing trend of EBV infection over the study period. Primary EBV infection was found in 7.4% of the seropositive samples; of these, 47.3% were between 5 and 19 years. EBV reactivation was found in 11% of the seropositive samples; of these, 50% were > 25 years of age. The youngest seropositive patient was 11 months old. EBV is a common viral infection in Bahrain. Most primary infections occur between 1 and 5 years while most reactivation infections occur after the age of 25 years. Serial surveillance of EBV infection is needed in Bahrain. Measures to protect against EBV infections should be implemented.
在巴林，缺乏有关 EBV 感染率的充分流行病学信息，这对于制定预防 EBV 感染的措施可能会有所帮助。本研究旨在调查 2001-2015 年这 15 年间巴林 EBV 感染的趋势。评估了 10560 名疑似 EBV 感染患者的 EBV 血清学结果。纳入了 2001-2015 年在萨勒曼尼亚医疗综合体采集的样本。记录了 EBV 病毒衣壳抗原 (VCA) IgG、VCA IgM 和 EBV 核抗原 (EBNA) IgG 抗体的存在或缺失情况。在 10560 个样本中，有 10333 个是可用的；其中，86.1%呈血清阳性，呈 EBV 感染呈上升趋势。在阳性血清样本中发现了 7.4%的原发性 EBV 感染；其中，47.3%在 5-19 岁之间。在阳性血清样本中发现了 11%的 EBV 再激活；其中，50%年龄>25 岁。最年轻的阳性血清患者为 11 个月大。EBV 是巴林常见的病毒感染。大多数原发性感染发生在 1 至 5 岁之间，而大多数再激活感染发生在 25 岁之后。巴林需要对 EBV 感染进行连续监测。应实施预防 EBV 感染的措施。
