Saeki T, Kuninobu H, Niimoto M, Hattori T, Ohoya M, Yoshida H, Sata H, Kajitani Y
Gan No Rinsho. 1987 Apr;33(4):417-20.
Intratumoral administration of 5 K.E. OK-423 was given every other day for a patient with an abdominal wall recurrence of gastric cancer. After a total dose of 465 K.E. the abdominal tumor turned necrotic and its demarcation was monitored. Finally, the tumor separated and fell from the abdominal wall. Histologically, marked infiltration of neutrophils, lymphocytes, and macrophages were observed in the cancerous tissue. Clinically, local pain lessened and the serum CEA level decreased. PPD and PHA skin tests were markedly stimulated. A long term small-dose intratumoral administration of OK-432 seemed to be effective for a local recurrence of gastric cancer.
对于一名胃癌腹壁复发患者，每隔一天进行瘤内注射5 K.E. 的OK-423。在总剂量达到465 K.E. 后，腹部肿瘤发生坏死，并对其边界进行监测。最终，肿瘤分离并从腹壁脱落。组织学检查显示，癌组织中有明显的中性粒细胞、淋巴细胞和巨噬细胞浸润。临床上，局部疼痛减轻，血清癌胚抗原（CEA）水平下降。结核菌素纯蛋白衍生物（PPD）和植物血凝素（PHA）皮肤试验受到明显刺激。长期小剂量瘤内注射OK-432似乎对胃癌局部复发有效。
