Nakazawa S, Yoshino J, Kijima Y, Yasumasa N, Ohhashi S, Mizutani K
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Endoscopy. 1989 Jul;21(4):168-71. doi: 10.1055/s-2007-1012934.
In eleven patients with gastric cancer who could not be operated on because of advanced age, refusal of surgery, or the presence of complications, the streptococcal preparation OK-432 was administered, both intradermally and by direct injection into the tumor under endoscopic guidance. Via gastric x-ray and endoscopic examinations, the tumor was observed to disappear in two cases-one advanced cancer and one early gastric cancer endoscopically. Particularly in the latter case repeated biopsies revealed no evidence of cancer cells. All patients developed fever after intratumor injection, but in no case was it necessary to discontinue administration, and no other serious side effects were noted. The endoscopic injection of OK-432 appears to be a safe and useful form of therapy for gastric cancer unsuitable for surgery.
对于11例因高龄、拒绝手术或存在并发症而无法进行手术的胃癌患者，给予链球菌制剂OK - 432，采用皮内注射以及在内镜引导下直接注射到肿瘤内的方式给药。通过胃X线和内镜检查，观察到2例肿瘤消失，其中1例为进展期癌，1例为早期胃癌（内镜下观察）。特别是在后一例中，反复活检未发现癌细胞迹象。所有患者在瘤内注射后均出现发热，但无一例需要停药，也未观察到其他严重副作用。对于不适合手术的胃癌患者，内镜下注射OK - 432似乎是一种安全有效的治疗方式。
