Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Pediatr Blood Cancer. 2018 Aug;65(8):e27025. doi: 10.1002/pbc.27025. Epub 2018 Mar 12.
In adolescents and young adults, thyroid cancer accounts for 13% of all invasive neoplasms, being three times more frequent in females, but overdiagnosis and overtreatment are common. There are two therapeutic approaches, one radical and no longer preferred in all instances, and the other conservative. Permanent complications of surgery and metabolic irradiation can affect quality of life and carry an economic burden. The overall survival rate approaches 100% for patients with differentiated thyroid cancer regardless of the extent of treatment. Medullary thyroid carcinoma is a very different entity, occurring most frequently in the context of hereditary tumor susceptibility syndromes.
在青少年和年轻人中,甲状腺癌占所有侵袭性肿瘤的 13%,女性发病率是男性的三倍,但过度诊断和过度治疗很常见。有两种治疗方法,一种是激进的,不再在所有情况下首选,另一种是保守的。手术和代谢性辐射的永久性并发症会影响生活质量并带来经济负担。无论治疗程度如何,分化型甲状腺癌患者的总体生存率都接近 100%。甲状腺髓样癌是一种非常不同的实体瘤,最常发生在遗传性肿瘤易感性综合征的背景下。